EC 1.1.1.358 - 2-dehydropantolactone reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.358

Names

Accepted name:
2-dehydropantolactone reductase
Other names:
2-oxopantoyl lactone reductase
2-ketopantoyl lactone reductase
ketopantoyl lactone reductase
2-dehydropantoyl-lactone reductase
Systematic name:
(R)-pantolactone:NADP+ oxidoreductase

Reaction

Comments:

The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Hata, H., Shimizu, S., Hattori, S., Yamada, H.
    Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase.
    Biochim. Biophys. Acta 990 : 175-181 (1989). [PMID: 2644973]

[EC 1.1.1.358 created 2013]