EC 1.1.1.356 - GDP-L-colitose synthase

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IntEnz Enzyme Nomenclature
EC 1.1.1.356

Names

Accepted name:
GDP-L-colitose synthase
Other name:
ColC
Systematic name:
GDP-β-L-colitose:NAD(P)+ 4-oxidoreductase (5-epimerizing)

Reactions

Comments:

The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Alam, J., Beyer, N., Liu, H. W.
    Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC).
    Biochemistry 43: 16450-16460 (2004). [PMID: 15610039]

[EC 1.1.1.356 created 2013]