IntEnz

EC 1.1.1.354 - Farnesol dehydrogenase (NAD⁺)

IntEnz Enzyme Nomenclature
EC 1.1.1.354

Names

Reaction

• 37167 [IUBMB]
  (2E,6E)-farnesol

  (2E,6E)-farnesol

  Name origin: UniProt - CHECKED (C)

  CHEBI:16619

  Formula: C15H26O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  (2E,6E)-farnesal

  (2E,6E)-farnesal

  Name origin: UniProt - CHECKED (C)

  CHEBI:15894

  Formula: C15H24O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. 1.1.1.347, geraniol dehydrogenase (NAD⁺)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP⁺), this enzyme cannot use NADP⁺ as cofactor.

Links to other databases

References

1. Noge, K., Kato, M., Mori, N., Kataoka, M., Tanaka, C., Yamasue, Y., Nishida, R., Kuwahara, Y.
   Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).
   FEBS J. 275: 2807-2817 (2008). [PMID: 18422649]

[EC 1.1.1.354 created 2013]