IntEnz

EC 1.1.1.350 - Ureidoglycolate dehydrogenase (NAD⁺)

IntEnz Enzyme Nomenclature
EC 1.1.1.350

Names

Reaction

• 15329 [IUBMB]
  (S)-ureidoglycolate

  (S)-ureidoglycolate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57296

  Formula: C3H5N2O4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  N-carbamoyl-2-oxoglycine

  N-carbamoyl-2-oxoglycine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57824

  Formula: C3H3N2O4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+].

Links to other databases

References

1. Cusa, E., Obradors, N., Baldoma, L., Badia, J., Aguilar, J.
   Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
   J. Bacteriol. 181 : 7479-7484 (1999). [PMID: 10601204]
2. Kim, M. I., Shin, I., Cho, S., Lee, J., Rhee, S.
   Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization.
   PLoS ONE 7 : e52066 (2012). [PMID: 23284870]

[EC 1.1.1.350 created 2013]