EC - Hydroxymethylglutaryl-CoA reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
hydroxymethylglutaryl-CoA reductase (NADPH)
Other names:
3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
3-hydroxy-3-methylglutaryl-CoA reductase
S-3-hydroxy-3-methylglutaryl-CoA reductase
β-hydroxy-β-methylglutaryl coenzyme A reductase
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
NADPH-hydroxymethylglutaryl-CoA reductase
hydroxymethylglutaryl CoA reductase (NADPH)
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
HMG-CoA reductase
3-hydroxy-3-methylglutaryl-coenzyme A reductase
hydroxymethylglutaryl-CoA reductase (NADPH2)
Systematic name:
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)



The enzyme is inactivated by EC {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00064
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004420
CAS Registry Number: 9028-35-7
UniProtKB/Swiss-Prot: (68) [show] [UniProt]


  1. Bucher, N.L.R., Overath, P. and Lynen, F.
    β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
    Biochim. Biophys. Acta 40 : 491-501 (1960).
  2. Durr, I.F. and Rudney, H.
    The reduction of β-hydroxy-β-methylglutaryl coenzyme A to mevalonic acid.
    J. Biol. Chem. 235 : 2572-2578 (1960). [PMID: 13818862]
  3. Kawachi, T. and Rudney, H.
    Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver.
    Biochemistry 9 : 1700 (1970). [PMID: 4985697]

[EC created 1961]