EC - Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)

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IntEnz Enzyme Nomenclature


Accepted name:
sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
Systematic name:
L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase



This enzyme, isolated from the bacterium Chlorobium tepidum, catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC, sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Cho, S. H., Na, J. U., Youn, H., Hwang, C. S., Lee, C. H., Kang, S. O.
    Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum.
    Biochem. J. 340: 497-503 (1999). [PMID: 10333495]
  2. Supangat, S., Choi, Y. K., Park, Y. S., Son, D., Han, C. D., Lee, K. H.
    Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202-204 (2005). [PMID: 16510994]

[EC created 2012]