EC - Isoeugenol synthase

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IntEnz Enzyme Nomenclature


Accepted name:
isoeugenol synthase
Other names:
t-anol/isoeugenol synthase 1
Systematic name:
eugenol:NADP+ oxidoreductase (coniferyl acetate reducing)



The enzyme acts in the opposite direction. In Ocimum basilicum (sweet basil), Clarkia breweri, and Petunia hybrida only isoeugenol is formed [1,2]. However in Pimpinella anisum (anise) only anol is formed in vivo, although the cloned enzyme does produce isoeugenol [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Koeduka, T., Fridman, E., Gang, D. R., Vassao, D. G., Jackson, B. L., Kish, C. M., Orlova, I., Spassova, S. M., Lewis, N. G., Noel, J. P., Baiga, T. J., Dudareva, N., Pichersky, E.
    Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester.
    Proc. Natl. Acad. Sci. U.S.A. 103: 10128-10133 (2006). [PMID: 16782809]
  2. Koeduka, T., Louie, G. V., Orlova, I., Kish, C. M., Ibdah, M., Wilkerson, C. G., Bowman, M. E., Baiga, T. J., Noel, J. P., Dudareva, N., Pichersky, E.
    The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages.
    Plant J. 54: 362-374 (2008). [PMID: 18208524]
  3. Koeduka, T., Baiga, T. J., Noel, J. P., Pichersky, E.
    Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain.
    Plant Physiol. 149: 384-394 (2009). [PMID: 18987218]

[EC created 2012]