EC - 11-cis-retinol dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
11-cis-retinol dehydrogenase
Other name:
RDH5 (gene name)
Systematic name:
11-cis-retinol:NAD+ oxidoreductase



This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Simon, A., Hellman, U., Wernstedt, C., Eriksson, U.
    The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.
    J. Biol. Chem. 270 : 1107-1112 (1995). [PMID: 7836368]
  2. Wang, J., Chai, X., Eriksson, U., Napoli, J. L.
    Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.
    Biochem. J. 338 : 23-27 (1999). [PMID: 9931293]
  3. Liden, M., Romert, A., Tryggvason, K., Persson, B., Eriksson, U.
    Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.
    J. Biol. Chem. 276 : 49251-49257 (2001). [PMID: 11675386]
  4. Wu, Z., Yang, Y., Shaw, N., Bhattacharya, S., Yan, L., West, K., Roth, K., Noy, N., Qin, J., Crabb, J. W.
    Mapping the ligand binding pocket in the cellular retinaldehyde binding protein.
    J. Biol. Chem. 278 : 12390-12396 (2003). [PMID: 12536149]

[EC created 2011]