EC - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Other names:
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase
4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase
α-hydroxy-γ-carboxymuconic ε-semialdehyde dehydrogenase
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
Systematic name:
4-carboxy-2-hydroxymuconate semialdehyde hemiaceta:NADP+ 2-oxidoreductase



The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050606
CAS Registry Number: 67272-39-3


  1. Maruyama, K., Ariga, N., Tsuda, M. and Deguchi, K.
    Purification and properties of α-hydroxy-γ-carboxymuconic ε-semialdehyde dehydrogenase.
    J. Biochem. 83 : 1125-1134 (1978). [PMID: 26671]
  2. Maruyama, K.
    Isolation and identification of the reaction product of α-hydroxy-γ-carboxymuconic ε-semialdehyde dehydrogenase.
    J. Biochem. 86 : 1671-1677 (1979). [PMID: 528534]
  3. Maruyama, K.
    Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
    J. Biochem. 93 : 557-565 (1983). [PMID: 6841353]
  4. Masai, E., Momose, K., Hara, H., Nishikawa, S., Katayama, Y., Fukuda, M.
    Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6.
    J. Bacteriol. 182 : 6651-6658 (2000). [PMID: 11073908]

[EC created 1978 as EC, transferred 2011 to EC]