EC 1.1.1.310 - (S)-sulfolactate dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.310

Names

Accepted name:
(S)-sulfolactate dehydrogenase
Other names:
(2S)-3-sulfolactate dehydrogenase
SlcC
Systematic name:
(2S)-sulfolactate:NAD+ oxidoreductase

Reaction

Comments:

This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase. The enzyme is specific for NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00063
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102155
UniProtKB/Swiss-Prot:

References

  1. Denger, K., Cook, A. M.
    Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
    Microbiology 156: 967-974 (2010). [PMID: 20007648]

[EC 1.1.1.310 created 2011, modified 2013]