EC - D-xylose reductase

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IntEnz Enzyme Nomenclature


Accepted name:
D-xylose reductase
Other names:
monospecific xylose reductase
dual specific xylose reductase
NAD(P)H-dependent xylose reductase
xylose reductase
Systematic name:
xylitol:NAD(P)+ oxidoreductase



Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (22) [show] [UniProt]


  1. Neuhauser, W., Haltrich, D., Kulbe, K. D., Nidetzky, B.
    NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme.
    Biochem. J. 326 : 683-692 (1997). [PMID: 9307017]
  2. Nidetzky, B., Bruggler, K., Kratzer, R., Mayr, P.
    Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies.
    J. Agric. Food Chem. 51 : 7930-7935 (2003). [PMID: 14690376]
  3. Iablochkova, E. N., Bolotnikova, O. I., Mikhailova, N. P., Nemova, N. N., Ginak, A. I.
    The activity of xylose reductase and xylitol dehydrogenase in yeasts
    Mikrobiologiia 72 : 466-469 (2003). [PMID: 14526534]
  4. Chen, L. C., Huang, S. C., Chuankhayan, P., Chen, C. D., Huang, Y. C., Jeyakanthan, J., Pang, H. F., Men, L. C., Chen, Y. C., Wang, Y. K., Liu, M. Y., Wu, T. K., Chen, C. J.
    Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 : 419-421 (2009). [PMID: 19342796]
  5. Verduyn, C., Van Kleef, R., Frank, J., Schreuder, H., Van Dijken, J. P., Scheffers, W. A.
    Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis.
    Biochem. J. 226 : 669-677 (1985). [PMID: 3921014]
  6. Fernandes, S., Tuohy, M. G., Murray, P. G.
    Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity.
    J. Biosci. 34 : 881-890 (2009). [PMID: 20093741]
  7. Lee, J. K., Koo, B. S., Kim, S. Y.
    Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis.
    Appl. Environ. Microbiol. 69 : 6179-6188 (2003). [PMID: 14532079]
  8. Woodyer, R., Simurdiak, M., van der Donk, W. A., Zhao, H.
    Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa.
    Appl. Environ. Microbiol. 71 : 1642-1647 (2005). [PMID: 15746370]

[EC created 2010]