EC - Homoserine dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
homoserine dehydrogenase
Other names:
Systematic name:
L-homoserine:NAD(P)+ oxidoreductase



The yeast enzyme acts most rapidly with NAD+; the Neurospora enzyme with NADP+. The enzyme from Escherichia coli is a multi-functional protein, which also catalyses the reaction of EC (aspartate kinase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00800
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004412
CAS Registry Number: 9028-13-1
UniProtKB/Swiss-Prot: (31) [show] [UniProt]


  1. Black, S. and Wright, N.G.
    Homoserine dehydrogenase.
    J. Biol. Chem. 213 : 51-60 (1955).
  2. Starnes, W.L., Munk, P., Maul, S.B., Cunningham, G.N., Cox, D.J. and Shive, W.
    Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex.
    Biochemistry 11 : 677-687 (1972). [PMID: 4551091]
  3. Véron, M., Falcoz-Kelly, F. and Cohen, G.N.
    The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain.
    Eur. J. Biochem. 28 : 520-527 (1972). [PMID: 4562990]

[EC created 1961, modified 1976]