EC 22.214.171.124 - Homoserine dehydrogenase
IntEnz Enzyme Nomenclature
- L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H + H+
The yeast enzyme acts most rapidly with NAD+; the Neurospora enzyme with NADP+. The enzyme from Escherichia coli is a multi-functional protein, which also catalyses the reaction of EC 126.96.36.199 (aspartate kinase).
Links to other databases
Homoserine dehydrogenase.J. Biol. Chem. 213 : 51-60 (1955).
Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex.Biochemistry 11 : 677-687 (1972). [PMID: 4551091]
The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain.Eur. J. Biochem. 28 : 520-527 (1972). [PMID: 4562990]
[EC 188.8.131.52 created 1961, modified 1976]