EC 1.1.1.299 - Malate dehydrogenase [NAD(P)+]

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IntEnz Enzyme Nomenclature
EC 1.1.1.299

Names

Accepted name:
malate dehydrogenase [NAD(P)+]
Other names:
MdH II
NAD(P)+-dependent malate dehyrogenase
Systematic name:
(S)-malate:NAD(P)+ oxidoreductase

Reaction

Comments:

This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Thompson, H., Tersteegen, A., Thauer, R. K., Hedderich, R.
    Two malate dehydrogenases in Methanobacterium thermoautotrophicum.
    Arch. Microbiol. 170 : 38-42 (1998). [PMID: 9639601]

[EC 1.1.1.299 created 2009]