EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.1 - With NAD+ or NADP+ as acceptor
EC 1.1.1.299 - Malate dehydrogenase [NAD(P)+]
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.1.299
Names
Accepted name:
malate dehydrogenase [NAD(P)+]
Other
names:
MdH II
NAD(P)+-dependent malate dehyrogenase
NAD(P)+-dependent malate dehyrogenase
Systematic name:
(S)-malate:NAD(P)+ oxidoreductase
Reaction
- (S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+
Comments:
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).
Links to other databases
UniProtKB/Swiss-Prot:
MDH_AERPE
MDH_METKA
MDH_METMP
MDH_METST
MDH_METTH
MDH_METTM
References
-
Two malate dehydrogenases in Methanobacterium thermoautotrophicum.Arch. Microbiol. 170 : 38-42 (1998). [PMID: 9639601]
[EC 1.1.1.299 created 2009]