EC - 3-hydroxypropionate dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
3-hydroxypropionate dehydrogenase (NADP+)
Other names:
3-hydroxypropanoate dehydrogenase (NADP+)
3-hydroxypropionate:NADP+ oxidoreductase
Systematic name:
3-hydroxypropanoate:NADP+ oxidoreductase



Catalyses the reduction of malonate semialdehyde to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [1,2]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC [3]. Different from EC [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0035527
UniProtKB/Swiss-Prot: (36) [show] [UniProt]


  1. Strauss, G., Fuchs, G.
    Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.
    Eur. J. Biochem. 215 : 633-643 (1993). [PMID: 8354269]
  2. Berg, I. A., Kockelkorn, D., Buckel, W., Fuchs, G.
    A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
    Science 318 : 1782-1786 (2007). [PMID: 18079405]
  3. Hugler, M., Menendez, C., Schagger, H., Fuchs, G.
    Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation.
    J. Bacteriol. 184 : 2404-2410 (2002). [PMID: 11948153]

[EC created 2009]