EC - 4-phosphoerythronate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
4-phosphoerythronate dehydrogenase
Other names:
PdxB 4PE dehydrogenase
4PE dehydrogenase
4-O-phosphoerythronate dehydrogenase
erythronate-4-phosphate dehydrogenase
Systematic name:
4-phospho-D-erythronate:NAD+ 2-oxidoreductase




This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC, 2-oxoglutarate reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00063
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033711
UniProtKB/Swiss-Prot: (154) [show] [UniProt]


  1. Lam, H.M. and Winkler, M.E.
    Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12.
    J. Bacteriol. 172 : 6518-6528 (1990). [PMID: 2121717]
  2. Pease, A.J., Roa, B.R., Luo, W. and Winkler, M.E.
    Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coliK-12.
    J. Bacteriol. 184 : 1359-1369 (2002). [PMID: 11844765]
  3. Zhao, G. and Winkler, M.E.
    A novel α-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.
    J. Bacteriol. 178 : 232-239 (1996). [PMID: 8550422]
  4. Grant, G.A.
    A new family of 2-hydroxyacid dehydrogenases.
    Biochem. Biophys. Res. Commun. 165 : 1371-1374 (1989). [PMID: 2692566]
  5. Schoenlein, P.V., Roa, B.B. and Winkler, M.E.
    Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12.
    J. Bacteriol. 171 : 6084-6092 (1989). [PMID: 2681152]

[EC created 2006, modified 2016]