EC 1.1.1.287 - D-arabinitol dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature
EC 1.1.1.287

Names

Accepted name:
D-arabinitol dehydrogenase (NADP+)
Other names:
NADP+-dependent D-arabinitol dehydrogenase
ARD1p
D-arabinitol dehydrogenase 1
Systematic name:
D-arabinitol:NADP+ oxidoreductase

Reactions

Comments:

The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00058
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Link, T., Lohaus, G., Heiser, I., Mendgen, K., Hahn, M. and Voegele, R.T.
    Characterization of a novel NADP+-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae.
    Biochem. J. 389: 289-295 (2005). [PMID: 15796718]

[EC 1.1.1.287 created 2005]