EC 1.1.1.281 - GDP-4-dehydro-6-deoxy-D-mannose reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.281

Names

Accepted name:
GDP-4-dehydro-6-deoxy-D-mannose reductase
Other names:
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous]
GDP-6-deoxy-D-lyxo-4-hexulose reductase
Rmd
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Systematic name:
GDP-α-D-rhamnose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)

Reactions

Comments:

This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-α-D-rhamnose (GDP-6-deoxy-α-D-mannose). D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033705
UniProtKB/Swiss-Prot:

References

  1. Kneidinger, B., Graninger, M., Adam, G., Puchberger, M., Kosma, P., Zayni, S. and Messner, P.
    Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
    J. Biol. Chem. 276: 5577-5583 (2001). [PMID: 11096116]
  2. Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Mattila, P. and Renkonen, R.
    Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
    Eur. J. Biochem. 269: 593-601 (2002). [PMID: 11856318]

[EC 1.1.1.281 created 2004]