EC - GDP-L-fucose synthase

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IntEnz Enzyme Nomenclature


Accepted name:
GDP-L-fucose synthase
Other names:
GDP-fucose synthetase
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
Systematic name:
GDP-β-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)



Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050577
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Chang, S., Duerr, B. and Serif, G.
    An epimerase-reductase in L-fucose synthesis.
    J. Biol. Chem. 263 : 1693-1697 (1988). [PMID: 3338988]
  2. Mattila, P., Räbinä, J, Hortling, S., Jelin, J. and Renkonen, R.
    Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae.
    Glycobiology 10 : 1041-1047 (2000). [PMID: 11030750]
  3. Menon, S., Stahl, M., Kumar, R., Xu, G.-Y. and Sullivan, F.
    Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli.
    J. Biol. Chem. 274 : 26743-26750 (1999). [PMID: 10480878]
  4. Somers, W.S., Stahl, M.L. and Sullivan, F.X.
    GDP-fucose synthetase from Escherichia coli: Structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
    Structure 6 : 1601-1612 (1998). [PMID: 9862812]

[EC created 2002, modified 2003]