EC - L-lactate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
L-lactate dehydrogenase
Other names:
L-(+)-lactate dehydrogenase
L-lactic acid dehydrogenase
L-lactic dehydrogenase
NAD-lactate dehydrogenase
lactate dehydrogenase
lactate dehydrogenase NAD-dependent
lactic acid dehydrogenase
lactic dehydrogenase
Systematic name:
(S)-lactate:NAD+ oxidoreductase



Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00062
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004459
CAS Registry Number: 9001-60-9
UniProtKB/Swiss-Prot: (315) [show] [UniProt]


  1. Dennis, D. and Kaplan, N.O.
    D and L-lactic acid dehydrogenase in Lactobacillus plantarum.
    J. Biol. Chem. 235 : 810-818 (1960).
  2. Everse, J. and Kaplan, N.O.
    Lactate dehydrogenases: structure and function.
    Adv. Enzymol. Relat. Subj. Biochem. 37 : 61-133 (1973). [PMID: 4146647]
  3. Holbrook, J.J., Liljas, A., Steindel, S.J. and Rossmann, M.G.
    Lactate dehydrogenase.
    In: Boyer, P.D. (Ed.) The Enzymes , 3rd ed. vol. 11 , Academic Press , New York , 1975 , 191-292
  4. Schär, H.-P. and Zuber, H.
    Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. I) Isolation and characterization of lactate dehydrogenases from thermophilic and mesophilic bacilli.
    Hoppe-Seyler's Z. Physiol. Chem. 360 : 795-807 (1979). [PMID: 114469]

[EC created 1961]