EC - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
1-deoxy-D-xylulose-5-phosphate reductoisomerase
Other names:
1-deoxy-D-xylulose-5-phosphate isomeroreductase
2C-methyl-D-erythritol-4-phosphate (MEP) synthase
1-deoxyxylulose-5-phosphate reductoisomerase
Systematic name:
2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)




The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. The mechanism has been shown to be a retroaldol/aldol reaction [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030604
CAS Registry Number: 210756-42-6
UniProtKB/Swiss-Prot: (446) [show] [UniProt]


  1. Takahashi, S., Kuzuyama, T., Watanabe, H. and Seto, H.
    A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.
    Proc. Natl. Acad. Sci. USA 95 : 9879-9884 (1998). [PMID: 9707569]
  2. Munos, J. W., Pu, X., Mansoorabadi, S. O., Kim, H. J., Liu, H. W.
    A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement.
    J. Am. Chem. Soc. 131 : 2048-2049 (2009). [PMID: 19159292]

[EC created 2001]