EC - Mannitol dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
mannitol dehydrogenase
Other names:
NAD-dependent mannitol dehydrogenase
Systematic name:
mannitol:NAD+ 1-oxidoreductase



The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046029
CAS Registry Number: 144941-29-7


  1. Stoop, J.M.H. and Pharr, D.M.
    Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots.
    Arch. Biochem. Biophys. 298: 612-619 (1992). [PMID: 1416989]
  2. Stoop, J.M.H., Williamson, J.D., Conkling, M.A. and Pharr, D.M.
    Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures.
    Plant Physiol. (1995) 108: 1219-1225 (1995). [PMID: 7630943]
  3. Williamson, J.D., Stoop, J.M.H., Massel, M.O., Conkling, M.A. and Pharr, D.M.
    Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3.
    Proc. Natl. Acad. Sci. USA 92: 7148-7152 (1995). [PMID: 7638158]
  4. Stoop, J.M.H., Chilton, W.S. and Pharr, D.M.
    Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery.
    Phytochemistry 43: 1145-1150 (1996).

[EC created 2000]