EC - Shikimate dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
shikimate dehydrogenase (NADP+)
Other names:
5-dehydroshikimate reductase
5-dehydroshikimic reductase
DHS reductase
dehydroshikimic reductase
shikimate 5-dehydrogenase
shikimate oxidoreductase
shikimate:NADP+ 5-oxidoreductase
shikimate:NADP+ oxidoreductase
shikimate dehydrogenase [ambiguous]
Systematic name:
shikimate:NADP+ 3-oxidoreductase



NAD+ cannot replace NADP+ [3]. In higher organisms, this enzyme forms part of a multienzyme complex with EC, 3-dehydroquinate dehydratase [4]. cf. EC, quinate/shikimate dehydrogenase (NAD+), EC, quinate/shikimate dehydrogenase (quinone), and EC, quinate/shikimate dehydrogenase [NAD(P)+].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004764
CAS Registry Number: 9026-87-3
UniProtKB/Swiss-Prot: (537) [show] [UniProt]


  1. Balinsky, D. and Davies, D.D.
    Aromatic biosynthesis in higher plants. 1. Preparation and properties of dehydroshikimic reductase.
    Biochem. J. 80 : 292-296 (1961). [PMID: 13686342]
  2. Mitsuhashi, S. and Davis, B.D.
    Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase.
    Biochim. Biophys. Acta 15 : 268-280 (1954). [PMID: 13208693]
  3. Yaniv, H. and Gilvarg, C.
    Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase.
    J. Biol. Chem. 213 : 787-795 (1955). [PMID: 14367339]
  4. Chaudhuri, S. and Coggins, J.R.
    The purification of shikimate dehydrogenase from Escherichia coli.
    Biochem. J. 226 : 217-223 (1985). [PMID: 3883995]
  5. Anton, I.A. and Coggins, J.R.
    Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase.
    Biochem. J. 249 : 319-326 (1988). [PMID: 3277621]
  6. Ye, S., Von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V. and McRee, D.E.
    The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode.
    J. Bacteriol. 185 : 4144-4151 (2003). [PMID: 12837789]

[EC created 1961, modified 1976, modified 2004]