EC - Codeinone reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
codeinone reductase (NADPH)
Systematic name:
codeine:NADP+ oxidoreductase



Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047036
CAS Registry Number: 153302-41-1


  1. Lenz, R. and Zenk, M.H.
    Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum.
    Tetrahedron Lett. 36: 2449-2452 (1995).
  2. Lenz, R. and Zenk, M.H.
    Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures.
    Eur. J. Biochem. 233: 132-139 (1995). [PMID: 7588736]

[EC created 1999, modified 2001]