EC - Hydroxyphenylpyruvate reductase

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IntEnz Enzyme Nomenclature


Accepted name:
hydroxyphenylpyruvate reductase
Other name:
Systematic name:
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase



The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102742 , GO:0047995
CAS Registry Number: 117590-77-9


  1. Petersen, M. and Alfermann, A.W.
    Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
    Z. Naturforsch. C: Biosci. 43 : 501-504 (1988).
  2. Kim, K. H., Janiak, V., Petersen, M.
    Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.
    Plant Mol. Biol. 54 : 311-323 (2004). [PMID: 15284489]
  3. Kim, Y. B., Uddina, M. R., Kim, Y., Park, C. G., Park, S. U.
    Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis.
    Nat Prod Commun 9 : 1311-1314 (2014). [PMID: 25918800]
  4. Wang, G. Q., Chen, J. F., Yi, B., Tan, H. X., Zhang, L., Chen, W. S.
    HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.
    Chin J Nat Med 15 : 917-927 (2017). [PMID: 29329649]

[EC created 1992, modified 2018]