EC 1.1.1.214 - 2-dehydropantolactone reductase (Si-specific)

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IntEnz Enzyme Nomenclature
EC 1.1.1.214

Names

Accepted name:
2-dehydropantolactone reductase (Si-specific)
Other names:
2-dehydropantoyl-lactone reductase (B-specific)
2-ketopantoyl lactone reductase
2-oxopantoyl lactone reductase
ketopantoyl lactone reductase
2-dehydropantolactone reductase (B-specific)
(R)-pantolactone:NADP+ oxidoreductase (B-specific)
Systematic name:
(R)-pantolactone:NADP+ oxidoreductase (Si-specific)

Reaction

Comments:

The Escherichia coli enzyme differs from that from yeast [EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific)], which is specific for the Re-face of NADP, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019141
CAS Registry Number: 37211-75-9

References

  1. Wilken, D.R., King, H.L., Jr. and Dyar, R.E.
    Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
    J. Biol. Chem. 250: 2311-2314 (1975). [PMID: 234966]

[EC 1.1.1.214 created 1986, modified 1999, modified 2013]