EC - 3α-hydroxysteroid dehydrogenase (Re-specific)

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IntEnz Enzyme Nomenclature


Accepted name:
3α-hydroxysteroid dehydrogenase (Re-specific)
Other names:
3α-hydroxysteroid dehydrogenase
3α-hydroxysteroid dehydrogenase (A-specific)
3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific)
Systematic name:
3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)



The enzyme acts on multiple 3α-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC, 3α-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC, 3α-hydroxysteroid 3-dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047026


  1. Björkhem, I. and Danielsson, H.
    Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by Δ4-3-oxosteroid 5-β-reductase and 3-α-hydroxysteroid dehydrogenase from rat liver.
    Eur. J. Biochem. 12: 80-84 (1970). [PMID: 4392180]
  2. Tomkins, G.M.
    A mammalian 3α-hydroxysteroid dehydrogenase.
    J. Biol. Chem. 218: 437-447 (1956). [PMID: 13278351]

[EC created 1986, modified 2012, modified 2013]