EC 1.1.1.211 - Long-chain-3-hydroxyacyl-CoA dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.211

Names

Accepted name:
long-chain-3-hydroxyacyl-CoA dehydrogenase
Other names:
3-hydroxyacyl-CoA dehydrogenase
β-hydroxyacyl-CoA dehydrogenase
LCHAD
long-chain 3-hydroxyacyl coenzyme A dehydrogenase
Systematic name:
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

Reaction

Comments:

This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with C16 substrates was 6- to 15-fold higher than with C4 substrates. (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016509
CAS Registry Number: 84177-52-6
UniProtKB/Swiss-Prot:

References

  1. El-Fakhri, M. and Middleton, B.
    The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
    Biochim. Biophys. Acta 713 : 270-279 (1982). [PMID: 7150615]

[EC 1.1.1.211 created 1986]