EC 126.96.36.199 - Tropinone reductase I
IntEnz Enzyme Nomenclature
tropinone reductase [ambiguous]
- tropine + NADP+ = tropinone + NADPH + H+
Also oxidizes other tropan-3α-ols, but not the corresponding β-derivatives . This enzyme along with EC 188.8.131.52, tropinone reductase II, represents a branch point in tropane alkaloid metabolism . Tropine (the product of EC 184.108.40.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 220.127.116.11) is the first specific metabolite on the pathway to the calystegines . Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific .
Links to other databases
Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium.Planta Med. 44 : 227-230 (1982).
Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia.Phytochemistry 30 : 801-805 (1991).
Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.Proc. Natl. Acad. Sci. USA 90 : 9591-9595 (1993). [PMID: 8415746]
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism.Phytochemistry 67 : 327-337 (2006). [PMID: 16426652]
[EC 18.104.22.168 created 1984, modified 2007]