EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.1 - With NAD+ or NADP+ as acceptor
EC 1.1.1.205 - IMP dehydrogenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.1.205
Names
Accepted name:
IMP dehydrogenase
Other
names:
IMP oxidoreductase
inosinate dehydrogenase
inosine 5'-monophosphate dehydrogenase
inosine monophosphate dehydrogenase
inosine monophosphate oxidoreductase
inosine-5'-phosphate dehydrogenase
inosinic acid dehydrogenase
inosinate dehydrogenase
inosine 5'-monophosphate dehydrogenase
inosine monophosphate dehydrogenase
inosine monophosphate oxidoreductase
inosine-5'-phosphate dehydrogenase
inosinic acid dehydrogenase
Systematic name:
IMP:NAD+ oxidoreductase
Reaction
-
11708 [IUBMB]+H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)+IMPName origin: UniProt - CHECKED (C)Formula: C10H11N4O8P
Charge: -2ChEBI compound status: CHECKED (C)NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)=+H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)+NADHName origin: UniProt - CHECKED (C)Formula: C21H27N7O14P2
Charge: -2ChEBI compound status: CHECKED (C)
Comments:
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00391
Gene Ontology:
GO:0003938
CAS Registry Number:
9028-93-7
References
-
Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of Aerobacter aerogenes.J. Biol. Chem. 226: 339-350 (1957). [PMID: 13428767]
-
Inosine 5-phosphate dehydrogenase of pea seeds.Biochem. J. 79: 147 (1961). [PMID: 13778733]
[EC 1.1.1.205 created 1961 as EC 1.2.1.14, transferred 1984 to EC 1.1.1.205]