EC - 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
Other names:
15-hydroxy PGD2 dehydrogenase
15-hydroxyprostaglandin dehydrogenase (NADP)
NADP-PGD2 dehydrogenase
NADP-dependent 15-hydroxyprostaglandin dehydrogenase
NADP-linked 15-hydroxyprostaglandin dehydrogenase
NADP-linked prostaglandin D2 dehydrogenase
NADP-specific 15-hydroxyprostaglandin dehydrogenase
dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)
dehydrogenase, prostaglandin D2
prostaglandin D2 dehydrogenase
prostaglandin-D 15-dehydrogenase (NADP)
Systematic name:
(5Z,13E)-(15S)-9α,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase



Specific for prostaglandins D [cf. EC 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 15-hydroxyprostaglandin dehydrogenase (NADP+)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047020
CAS Registry Number: 84399-95-1


  1. Watanabe, K., Shimizu, T., Iguchi, S., Wakatsuka, H., Hayashi, M. and Hayaishi, O.
    An NADP-linked prostaglandin D dehydrogenase in swine brain.
    J. Biol. Chem. 255 : 1779-1882 (1980). [PMID: 7354056]

[EC created 1984, modified 1990]