IntEnz

EC 1.1.1.19 - Glucuronate reductase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.1.1.19

Names

Accepted name:

glucuronate reductase

Other names:

D-glucuronate dehydrogenase
D-glucuronate reductase
L-hexonate:NADP dehydrogenase
NADP-L-gulonate dehydrogenase
TPN-L-gulonate dehydrogenase
aldehyde reductase
aldehyde reductase II
L-glucuronate reductase [incorrect]
glucuronate dehydrogenase

Systematic name:

L-gulonate:NADP⁺ 6-oxidoreductase

Reaction

14909 [IUBMB]

L-gulonate

L-gulonate

Name origin: UniProt - CHECKED (C)

CHEBI:13115

Formula: C6H11O7
Charge: -1

ChEBI compound status: CHECKED (C)

+

NADP⁺

NADP(+)

Name origin: UniProt - CHECKED (C)

CHEBI:58349

Formula: C21H25N7O17P3
Charge: -3

ChEBI compound status: CHECKED (C)

=

D-glucuronate

D-glucuronate

Name origin: UniProt - CHECKED (C)

CHEBI:58720

Formula: C6H9O7
Charge: -1

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

NADPH

NADPH

Name origin: UniProt - CHECKED (C)

CHEBI:57783

Formula: C21H26N7O17P3
Charge: -4

ChEBI compound status: CHECKED (C)

Comments:

Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP⁺)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0047939

CAS Registry Number: 9028-29-9

References

Sivak, A. and Hoffmann-Ostenhof, O.

Enzymes of meso-inositol catabolism in the yeast Schwanniomyces occidentalis.

Biochim. Biophys. Acta 53: 426-428 (1961).
von Wartburg, J.P. and Wermoth, B.

Aldehyde reductase.

In: Jakoby, W.B. (Ed.) Enzymatic Basis of Detoxication vol. 1, Academic Press, New York, 1980, 249-260
York, J.L., Grollman, A.P. and Bublitz, C.

TPN-L-gulonate dehydrogenase.

Biochim. Biophys. Acta 47: 298-306 (1961).

[EC 1.1.1.19 created 1961]

EC 1 - Oxidoreductases