EC 1.1.1.189 - Prostaglandin-E2 9-reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.189

Names

Accepted name:
prostaglandin-E2 9-reductase
Other names:
9-keto-prostaglandin E2 reductase
9-ketoprostaglandin reductase
PGE-9-ketoreductase
PGE2 9-oxoreductase
PGE2-9-OR
PGE2-9-ketoreductase
prostaglandin 9-ketoreductase
prostaglandin E 9-ketoreductase
prostaglandin E2-9-oxoreductase
reductase, 15-hydroxy-9-oxoprostaglandin
Systematic name:
(5Z,13E)-(15S)-9α,11α,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase

Reaction

Comments:

Reduces prostaglandin E2 to prostaglandin F2α. A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. May be identical with EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050221
CAS Registry Number: 42613-35-4
UniProtKB/Swiss-Prot:

References

  1. Lee, S.-C. and Levine, L.
    Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase.
    J. Biol. Chem. 250: 4549-4555 (1975). [PMID: 166995]
  2. Schlegel, W., Krüger, S. and Korte, K.
    Purification of prostaglandin E2 9-oxoreductase from human decidua vera.
    FEBS Lett. 171: 141-144 (1984). [PMID: 6586494]
  3. Tai, H.-H. and Yuan, B.
    Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney.
    Methods Enzymol. 86: 113-117 (1982). [PMID: 7132747]
  4. Watkins, J.D. and Jarabak, J.
    The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney.
    Prostaglandins 30: 335-349 (1985). [PMID: 3901124]

[EC 1.1.1.189 created 1984, modified 1989]