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EC 1.1.1.185 - L-glycol dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.185

Names

Accepted name:

L-glycol dehydrogenase

Other names:

L-(+)-glycol:NAD(P) oxidoreductase
L-glycol:NAD(P) dehydrogenase
glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase

Systematic name:

L-glycol:NAD(P)⁺ oxidoreductase

Reactions

10324 [IUBMB]

an L-glycol

an L-glycol

Name origin: UniProt - CHECKED (C)

CHEBI:27636

Formula: C2H5O2R
Charge: 0

ChEBI compound status: CHECKED (C)

+

NADP⁺

NADP(+)

Name origin: UniProt - CHECKED (C)

CHEBI:58349

Formula: C21H25N7O17P3
Charge: -3

ChEBI compound status: CHECKED (C)

=

a 2-hydroxycarbonyl

a 2-hydroxycarbonyl

Name origin: UniProt - CHECKED (C)

CHEBI:52501

Formula: C2H3O2R
Charge: 0

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

NADPH

NADPH

Name origin: UniProt - CHECKED (C)

CHEBI:57783

Formula: C21H26N7O17P3
Charge: -4

ChEBI compound status: CHECKED (C)
10328 [IUBMB]

an L-glycol

an L-glycol

Name origin: UniProt - CHECKED (C)

CHEBI:27636

Formula: C2H5O2R
Charge: 0

ChEBI compound status: CHECKED (C)

+

NAD⁺

NAD(+)

Name origin: UniProt - CHECKED (C)

CHEBI:57540

Formula: C21H26N7O14P2
Charge: -1

ChEBI compound status: CHECKED (C)

=

a 2-hydroxycarbonyl

a 2-hydroxycarbonyl

Name origin: UniProt - CHECKED (C)

CHEBI:52501

Formula: C2H3O2R
Charge: 0

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

NADH

NADH

Name origin: UniProt - CHECKED (C)

CHEBI:57945

Formula: C21H27N7O14P2
Charge: -2

ChEBI compound status: CHECKED (C)

Comments:

The 2-hydroxycarbonyl compound formed can be further oxidized to a vicinal dicarbonyl compound. In the reverse direction, vicinal diketones, glyceraldehyde, glyoxal, methylglyoxal, 2-oxo-hydroxyketones and 2-ketoacid esters can be reduced.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0050026

CAS Registry Number: 77967-75-0

References

Bernardo, A., Burgos, J. and Martin, R.

Purification and some properties of L-glycol dehydrogenase from hen's muscle.

Biochim. Biophys. Acta 659: 189-198 (1981). [PMID: 7018582]

[EC 1.1.1.185 created 1984]

EC 1 - Oxidoreductases