EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)

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IntEnz Enzyme Nomenclature
EC 1.1.1.168

Names

Accepted name:
2-dehydropantolactone reductase (Re-specific)
Other names:
2-dehydropantoyl-lactone reductase (A-specific)
2-ketopantoyl lactone reductase
2-oxopantoyl lactone reductase
ketopantoyl lactone reductase
2-dehydropantolactone reductase (A-specific)
(R)-pantolactone:NADP+ oxidoreductase (A-specific)
Systematic name:
(R)-pantolactone:NADP+ oxidoreductase (Re-specific)

Reaction

Comments:

The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047011
CAS Registry Number: 37211-75-9
UniProtKB/Swiss-Prot:

References

  1. King, H.L., Jr. and Wilken, D.R.
    Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase.
    J. Biol. Chem. 247: 4689-4695 (1972). [PMID: 4603075]
  2. Wilken, D.R., King, H.L., Jr. and Dyar, R.E.
    Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
    J. Biol. Chem. 250: 2311-2314 (1975). [PMID: 234966]

[EC 1.1.1.168 created 1976, modified 1986, modified 1999, modified 2013]