EC - Hydroxycyclohexanecarboxylate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
hydroxycyclohexanecarboxylate dehydrogenase
Other names:
(−)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase
dihydroxycyclohexanecarboxylate dehydrogenase
Systematic name:
(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase



Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (−)-quinate and (−)-shikimate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047010
CAS Registry Number: 55467-53-3


  1. Whiting, G.C. and Coggins, R.A.
    A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (−)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate.
    Biochem. J. 141: 35-42 (1974). [PMID: 4375976]

[EC created 1976]