IntEnz

EC 1.1.1.16 - Galactitol 2-dehydrogenase

IntEnz Enzyme Nomenclature
EC 1.1.1.16

Names

Reaction

• 20685 [IUBMB]
  galactitol

  galactitol

  Name origin: UniProt - CHECKED (C)

  CHEBI:16813

  Formula: C6H14O6
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  keto-D-tagatose

  keto-D-tagatose

  Name origin: UniProt - CHECKED (C)

  CHEBI:47693

  Formula: C6H12O6
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium rubrum C58 is part of D-altritol and galactitol degradation pathways.

Links to other databases

References

1. Shaw, D.R.D.
   Polyol dehydrogenases 3. Galactitol dehydrogenase and D-iditol dehydrogenase.
   Biochem. J. 64: 394-405 (1956).
2. Wichelecki, D. J., Vetting, M. W., Chou, L., Al-Obaidi, N., Bouvier, J. T., Almo, S. C., Gerlt, J. A.
   ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel D-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.
   J. Biol. Chem. 290: 28963-28976 (2015). [PMID: 26472925]

[EC 1.1.1.16 created 1961]