EC - 3β-hydroxy-Δ5-steroid dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
3β-hydroxy-Δ5-steroid dehydrogenase
Other names:
3β-hydroxy steroid dehydrogenase/isomerase
3β-hydroxy-5-ene steroid dehydrogenase
3β-hydroxy-5-ene-steroid dehydrogenase
3β-hydroxy-5-ene-steroid oxidoreductase
3β-hydroxy-Δ5-C27-steroid dehydrogenase/isomerase
3β-hydroxy-Δ5-C27-steroid oxidoreductase
5-ene-3-β-hydroxysteroid dehydrogenase
Δ5-3β-hydroxysteroid dehydrogenase
progesterone reductase
steroid-Δ5-3β-ol dehydrogenase
Systematic name:
3β-hydroxy-Δ5-steroid:NAD+ 3-oxidoreductase



Acts on 3β-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17-dione and on 3β-hydroxypregn-5-en-20-one to form progesterone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003854 , GO:0102294
CAS Registry Number: 9044-85-3
UniProtKB/Swiss-Prot: (23) [show] [UniProt]


  1. Cheatum, S.G. and Warren, J.C.
    Purification and properties of 3-β-hydroxysteroid dehydrogenase and Δ-5-3-ketosteroid isomerase from bovine corpora lutea.
    Biochim. Biophys. Acta 122: 1-13 (1966). [PMID: 4226148]
  2. Koritz, S.B.
    The conversion of prepnenolone to progesterone by small particle from rat adrenal.
    Biochemistry 3: 1098-1102 (1964). [PMID: 14220672]
  3. Neville, A.M., Orr, J.C. and Engel, L.L.
    Δ5-3β-Hydroxy steroid dehydrogenase activities of bovine adrenal cortex.
    Biochem. J. 107: 20P (1968).

[EC created 1972]