EC - L-iditol 2-dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
L-iditol 2-dehydrogenase
Other names:
L-iditol (sorbitol) dehydrogenase
L-iditol:NAD oxidoreductase
L-iditol:NAD+ 5-oxidoreductase
NAD-dependent sorbitol dehydrogenase
NAD-sorbitol dehydrogenase
NAD+-dependent sorbitol dehydrogenase
glucitol dehydrogenase
polyol dehydrogenase
sorbitol dehydrogenase
Systematic name:
L-iditol:NAD+ 2-oxidoreductase



This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00058
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003939
CAS Registry Number: 9028-21-1
UniProtKB/Swiss-Prot: (13) [show] [UniProt]


  1. Bailey, J.P., Renz, C. and McGuinness, E.T.
    Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties.
    Comp. Biochem. Physiol. 69B : 909-914 (1981).
  2. Burnell, J.N. and Holmes, R.S.
    Purification and properties of sorbitol dehydrogenase from mouse liver.
    Int. J. Biochem. 15 : 507-511 (1983). [PMID: 6852349]
  3. Leissing, N. and McGuinness, E.T.
    Rapid affinity purification and properties of rat liver sorbitol dehydrogenase.
    Biochim. Biophys. Acta 524 : 254-261 (1978). [PMID: 667078]
  4. Negm, F.B. and Loescher, W.H.
    Detection and characterization of sorbitol dehydrogenase from apple callus tissue.
    Plant Physiol. 64 : 69-73 (1979).
  5. O'Brien, M.M., Schofield, P.J. and Edwards, M.R.
    Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase.
    Biochem. J. 211 : 81-90 (1983). [PMID: 6870831]
  6. Ng, K., Ye, R., Wu, X. C., Wong, S. L.
    Sorbitol dehydrogenase from Bacillus subtilis. Purification, characterization, and gene cloning.
    J. Biol. Chem. 267 : 24989-24994 (1992). [PMID: 1460002]

[EC created 1961, modified 2011]