EC - 3-dehydrosphinganine reductase

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IntEnz Enzyme Nomenclature


Accepted name:
3-dehydrosphinganine reductase
Other names:
3-oxosphinganine reductase
3-oxosphinganine:NADPH oxidoreductase
D-3-dehydrosphinganine reductase
D-3-oxosphinganine reductase
D-3-oxosphinganine:B-NADPH oxidoreductase
Systematic name:
D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047560
CAS Registry Number: 37250-36-5
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Stoffel, W., Le Kim, D. and Sticht, G.
    Biosynthesis of dihydrosphingosine in vitro.
    Hoppe-Seyler's Z. Physiol. Chem. 349: 664-670 (1968). [PMID: 4386961]
  2. Stoffel, W., Le Kim, D. and Sticht, G.
    Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).
    Hoppe-Seyler's Z. Physiol. Chem. 349: 1637-1644 (1968). [PMID: 4387676]

[EC created 1972]