EC 3 - Hydrolases
EC 3.5 - Acting on carbon-nitrogen bonds, other than peptide bonds
EC 3.5.4 - In cyclic amidines
EC 3.5.4.8 - Aminoimidazolase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.5.4.8
Names
Accepted name:
aminoimidazolase
Other
names:
4-aminoimidazole hydrolase
4-aminoimidazole deaminase
4-aminoimidazole deaminase
Systematic name:
4-aminoimidazole aminohydrolase
Reaction
- 4-aminoimidazole + H2O = imidazol-4-one + NH3
Cofactor
Comments:
Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
Links to other databases
Gene Ontology:
GO:0047664
CAS Registry Number:
9025-17-6
References
-
Purine fermentation by Clostridium cylindrosporum. V. Formiminoglycine.J. Biol. Chem. 222 : 537-554 (1956). [PMID: 13367024]
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Labile Stoffwechselprodukte. V. Zur Biogenese des Formiminoglycins aus 4(5H)-imidazolon.Ann. Chem. 607 : 174-187 (1957).
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Degradation of purines and pyrimidines by microorganisms.Bacteriol. Rev. 40 : 403-468 (1976). [PMID: 786256]
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Erratum report. Degradation of purines and pyrimidines by microorganisms.Bacteriol. Rev. 40 : 963 (1976).
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Purine metabolism in Methanococcus vannielii.J. Bacteriol. 175 : 5754-5761 (1993). [PMID: 8376322]
[EC 3.5.4.8 created 1961]