EC - Phosphatidylinositol-4,5-bisphosphate 3-kinase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphatidylinositol-4,5-bisphosphate 3-kinase
Other name:
type I phosphoinositide 3-kinase
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase



This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052812 , GO:0046934
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D.
    Synthesis and function of 3-phosphorylated inositol lipids.
    Annu. Rev. Biochem. 70: 535-602 (2001). [PMID: 11395417]

[EC created 2002]