IntEnz

EC 2.7.1.137 - Phosphatidylinositol 3-kinase

IntEnz Enzyme Nomenclature
EC 2.7.1.137

Names

Reaction

• 12709 [IUBMB]
  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57880

  Formula: C11H16O13PR2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)

  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58088

  Formula: C11H15O16P2R2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

One mammalian isoform is known.

Links to other databases

References

1. Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L.
   Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
   Nature 332 : 644-646 (1988). [PMID: 2833705]
2. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D.
   Synthesis and function of 3-phosphorylated inositol lipids.
   Annu. Rev. Biochem. 70 : 535-602 (2001). [PMID: 11395417]

[EC 2.7.1.137 created 1992, modified 2002]