EC - DNA (cytosine-5-)-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
DNA (cytosine-5-)-methyltransferase
Other names:
EcoRI methylase
DNA 5-cytosine methylase
DNA cytosine c5 methylase
DNA cytosine methylase
DNA methylase
DNA methyltransferase
DNA transmethylase
DNA-cytosine 5-methylase
DNA-cytosine methyltransferase
HpaII methylase
HpaII' methylase
Typ II DNA methylase
cytosine 5-methyltransferase
cytosine DNA methylase
cytosine DNA methyltransferase
cytosine-specific DNA methyltransferase
deoxyribonucleate methylase
deoxyribonucleate methyltransferase
deoxyribonucleic (cytosine-5-)-methyltransferase
deoxyribonucleic acid (cytosine-5-)-methyltransferase
deoxyribonucleic acid methylase
deoxyribonucleic acid methyltransferase
deoxyribonucleic acid modification methylase
deoxyribonucleic methylase
methylphosphotriester-DNA methyltransferase
modification methylase
restriction-modification system
site-specific DNA-methyltransferase (cytosine-specific)
Systematic name:
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00089
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003886
CAS Registry Number: 9037-42-7
UniProtKB/Swiss-Prot: (101) [show] [UniProt]


  1. Gold, M. and Hurwitz, J.
    The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. V. Purification and properties of the deoxyribonucleic acid-methylating activity of Escherichia coli.
    J. Biol. Chem. 239: 3858-2865 (1964).
  2. Kalousek, F. and Morris, N.R.
    The purification and properties of deoxyribonucleic acid methylase from rat spleen.
    J. Biol. Chem. 244: 1157-1163 (1969). [PMID: 4975067]
  3. Roy, P.H. and Weissbach, A.
    DNA methylase from HeLa cell nuclei.
    Nucleic Acids Res. 2: 1669-1684 (1975). [PMID: 1187340]
  4. Simon, D., Grunert, F., Acken, U.Y., Döring, H.P. and Kröger, H.
    DNA-methylase from regenerating rat liver: purification and characterisation.
    Nucleic Acids Res. 5: 2153-2167 (1978). [PMID: 673848]
  5. Sneider, T.W., Teague, W.M. and Rogachewsky, L.M.
    S-Adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line.
    Nucleic Acids Res. 2: 1685-1700 (1975). [PMID: 171625]
  6. Turnbull, J.F. and Adams, R.L.P.
    DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity.
    Nucleic Acids Res. 3: 677-695 (1976). [PMID: 131936]
  7. Kessler, C. and Manta, V.
    Specificity of restriction endonucleases and DNA modification methyltransferases: a review.
    Gene 92: 1-248 (1990). [PMID: 91032997]
  8. Roberts, R.J.
    Restriction enzymes and their isoschizomers.
    Nucleic Acids Res. 18: 2331-2365 (1990). [PMID: 2159140]
  9. Yuan, R.
    Structure and mechanism of multifunctional restriction endonucleases.
    Annu. Rev. Biochem. 50: 285-319 (1981). [PMID: 6267988]

[EC created 1972, modified 2003]