{"data":[{"object":"interactor","id":"complex portal_CPX-5709","type":{"id":"MI:1302","name":"stable complex"},"organism":{"taxid":"694009","common":"sars-cov","scientific":"Human SARS coronavirus"},"identifier":{"db":"complex portal","id":"CPX-5709"},"label":"nsp10-nsp16_cvhsa"},{"object":"interactor","id":"chebi_CHEBI:149612","type":{"id":"MI:0328","name":"small molecule"},"organism":{"taxid":"-2","common":"chemical synthesis","scientific":"Chemical synthesis (Chemical synthesis)"},"identifier":{"db":"chebi","id":"CHEBI:149612"},"label":"7meg5'-ppp5'accccc"},{"object":"interactor","id":"chebi_CHEBI:15414","type":{"id":"MI:0328","name":"small molecule"},"organism":{"taxid":"-2","common":"chemical synthesis","scientific":"Chemical synthesis (Chemical synthesis)"},"identifier":{"db":"chebi","id":"CHEBI:15414"},"label":"s-adenosyl-l-methionine"},{"object":"interaction","id":"intact_EBI-25570228","interactionType":{"id":"MI:0213","name":"methylation reaction"},"experiment":{"detmethod":{"id":"MI:0515","name":"methyltransferase assay"},"host":{"taxid":"-1","common":"in vitro","scientific":"In vitro"},"pubid":[{"db":"intact","id":"EBI-25504643"},{"db":"pubmed","id":"21637813"},{"db":"imex","id":"IM-27883"}],"sourceDatabase":{"id":"MI:0469","name":"European Bioinformatics Institute"},"figures":["Tables 2, S1, S2"]},"identifiers":[{"db":"intact","id":"EBI-25570228"},{"db":"imex","id":"IM-27883-9"}],"participants":[{"id":"1","interactorRef":"complex portal_CPX-5709","bioRole":{"id":"MI:0501","name":"enzyme"},"expRole":{"id":"MI:0497","name":"neutral component"},"identificationMethods":[{"id":"MI:0833","name":"autoradiography"}],"expressedIn":{"taxid":"83333","common":"ecoli","scientific":"Escherichia coli (strain K12)"},"features":[{"id":"2","name":"P0C6X7-PRO_0000037322:p.Asp106Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"106-106","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"4","name":"P0C6X7-PRO_0000037317:p.Arg78Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"78-78","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"6","name":"P0C6X7-PRO_0000037322:p.Asn43Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"43-43","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"7","name":"P0C6X7-PRO_0000037322:p.Asp130Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"130-130","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"8","name":"P0C6X7-PRO_0000037322:p.Lys46Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"46-46","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"9","name":"P0C6X7-PRO_0000037317:p.Leu45Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"45-45","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"10","name":"P0C6X7-PRO_0000037322:p.Gln87Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"87-87","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"11","name":"P0C6X7-PRO_0000037322:p.Lys170Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"170-170","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"12","name":"P0C6X7-PRO_0000037317:p.Thr58Ala","category":"pointMutations","type":{"id":"MI:1131","name":"mutation increasing interaction rate"},"sequenceData":[{"pos":"58-58","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"13","name":"P0C6X7-PRO_0000037322:p.Tyr30Phe","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"30-30","resultingSequence":"F","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"14","name":"P0C6X7-PRO_0000037317:p.Gly70Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"70-70","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"15","name":"P0C6X7-PRO_0000037322:p.Arg86Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"86-86","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"16","name":"P0C6X7-PRO_0000037322:p.Met247Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"247-247","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"17","name":"P0C6X7-PRO_0000037322:p.Met41Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"41-41","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"18","name":"P0C6X7-PRO_0000037322:p.Ser188Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"188-188","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"19","name":"P0C6X7-PRO_0000037322:p.Val104Gly","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"104-104","resultingSequence":"G","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"20","name":"P0C6X7-PRO_0000037322:p.Tyr132Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"132-132","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"21","name":"P0C6X7-PRO_0000037317:p.Thr47Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"47-47","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"22","name":"P0C6X7-PRO_0000037317:p.His80Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"80-80","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"23","name":"P0C6X7-PRO_0000037317:p.Gly94Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"94-94","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"24","name":"P0C6X7-PRO_0000037322:p.Tyr132His","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"132-132","resultingSequence":"H","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"25","name":"P0C6X7-PRO_0000037322:p.Thr48Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"48-48","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"26","name":"P0C6X7-PRO_0000037317:p.Val42Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"42-42","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"27","name":"P0C6X7-PRO_0000037322:p.Glu203Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"203-203","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"28","name":"P0C6X7-PRO_0000037322:p.Asp99Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"99-99","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"29","name":"P0C6X7-PRO_0000037322:p.Val44Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"44-44","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"30","name":"P0C6X7-PRO_0000037317:p.Lys93Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"93-93","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"31","name":"P0C6X7-PRO_0000037322:p.Val78Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"78-78","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"32","name":"P0C6X7-PRO_0000037317:p.His80Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"80-80","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"33","name":"P0C6X7-PRO_0000037317:p.Tyr96Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"96-96","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"34","name":"P0C6X7-PRO_0000037322:p.Thr58Asn","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"58-58","resultingSequence":"N","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"35","name":"P0C6X7-PRO_0000037322:p.Leu244Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"244-244","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"36","name":"P0C6X7-PRO_0000037322:p.Tyr132Phe","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"132-132","resultingSequence":"F","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"37","name":"P0C6X7-PRO_0000037317:p.Val57Ala","category":"pointMutations","type":{"id":"MI:2226","name":"mutation with no effect"},"sequenceData":[{"pos":"57-57","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"38","name":"P0C6X7-PRO_0000037322:p.Tyr30Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"30-30","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"39","name":"P0C6X7-PRO_0000037322:p.Ile40Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"40-40","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"40","name":"P0C6X7-PRO_0000037322:p.Tyr132Thr","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"132-132","resultingSequence":"T","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"41","name":"P0C6X7-PRO_0000037317:p.Asn40Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"40-40","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"42","name":"P0C6X7-PRO_0000037317:p.Lys95Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"95-95","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"43","name":"P0C6X7-PRO_0000037322:p.Gly73Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"73-73","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"44","name":"P0C6X7-PRO_0000037317:p.Met44Ala","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"44-44","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]},{"id":"45","name":"P0C6X7-PRO_0000037322:p.Thr58Glu","category":"pointMutations","type":{"id":"MI:1129","name":"mutation disrupting interaction rate"},"sequenceData":[{"pos":"58-58","resultingSequence":"E","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"46","name":"P0C6X7-PRO_0000037322:p.Thr58Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"58-58","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037322","participantRef":"3"}]},{"id":"47","name":"P0C6X7-PRO_0000037317:p.Ser72Ala","category":"pointMutations","type":{"id":"MI:1130","name":"mutation decreasing interaction rate"},"sequenceData":[{"pos":"72-72","resultingSequence":"A","interactorRef":"uniprotkb_P0C6X7-PRO_0000037317","participantRef":"5"}]}]},{"id":"48","interactorRef":"chebi_CHEBI:149612","bioRole":{"id":"MI:0919","name":"acceptor"},"expRole":{"id":"MI:0497","name":"neutral component"},"identificationMethods":[{"id":"MI:0833","name":"autoradiography"}],"expressedIn":{"taxid":"83333","common":"ecoli","scientific":"Escherichia coli (strain K12)"}},{"id":"49","interactorRef":"chebi_CHEBI:15414","bioRole":{"id":"MI:0918","name":"donor"},"expRole":{"id":"MI:0497","name":"neutral component"},"identificationMethods":[{"id":"MI:0833","name":"autoradiography"}],"expressedIn":{"taxid":"-2","common":"chemical synthesis","scientific":"Chemical synthesis (Chemical synthesis)"},"features":[{"id":"50","name":"region","category":"experimentalFeatures","type":{"id":"MI:0238","name":"3h radiolabel"},"sequenceData":[{"pos":"?-?","interactorRef":"chebi_CHEBI:15414","participantRef":"49"}]}]}]}]}