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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 20562859

Journal: Nature (0028-0836)

Year of Publication: 2010

Title: Network organization of the human autophagy system.

Author List: Behrends C., Sowa ME., Gygi SP., Harper JW.

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Experiment (65 interactions)

Accession: EBI-3183386

Name: behrends-2010-1

Host organism: Homo sapiens 293 cells transformed with SV40 large T antigen

Organism: Homo sapiens 293 cells transformed with SV40 large T antigen

Accession: EBI-308002

Name: human-293t

Description: Homo sapiens 293 cells transformed with SV40 large T antigen

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human
-

Interaction Detection Method: anti tag coip

Interaction detection method: anti tag coip
Accession: EBI-90

Name: anti tag coip

Description: anti tag coimmunoprecipitation

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0007
-
identity
pubmed
7708014
-
primary-reference


Annotations:
Topic
Text
definition
A specific antibody for the molecule of interest is not available, therefore the bait protein is expressed as a hybrid protein fused to a tag peptide/protein for which efficient and specific antibodies or a specific ligand are available.


Participant Identification Method: sequence tag

Participant identification method: sequence tag
Accession: EBI-81

Name: sequence tag

Description: sequence tag identification

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0102
-
identity
pubmed
10967324
-
primary-reference
pubmed
11752590
-
primary-reference
pubmed
11805837
-
primary-reference


Annotations:
Topic
Text
definition
This approach leads to protein identification by combining mass measurement and short amino acid sequence information obtained by tandem mass spectrometry. This information is then used to automatically find the best match in a sequence database. A mixture of peptides derived from a protease digestion is analysed by nanoelectrospray LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometer or nanoESI MS/MS) mass spectrometry. Electrospray mass spectrometry cannot be applied to dilute samples and is affected by high salt. As a consequence peptides, normally extracted from acrylamide gels by in situ proteolysis, are desalted and concentrated on a microcolumn followed by elution into a capillary used for nanoelectrospray tandem mass spectrometry. A first mass spectrum (Normal mass spectrum or Q1 mass spectrum) gives information about the masses of all the peptides. Peptides observed in the normal mass spectrum are isolated in turn and dissociated into fragments by collision with gas molecules within the mass spectrometer. Some of the fragments obtained from a peptide constitute a nested set, differing by one amino acid, and the mass difference between them allows assignment of a partial sequence. The masses of the fragments define the position of the partial sequence in the peptide. Together with the cleavage specificity of the protease used to cleave the protein, and mass information such sequence tag provides much higher search specificity to match the a database entry. The procedure is repeated with several peptides from the digest, resulting in multiple identifications of the same protein or identification of several proteins from the peptide mixture. Unknown proteins can easily be identified by using the high specificity of the peptide sequence tag for searches in most sequence databases including EST or genome databases.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
wade_harper@hms.harvard.edu
Participants were identified based on results from LTQ linear ion trap LC MS/MS.
Participants were identified based on results from LTQ linear ion trap LC MS/MS.
High-confidence candidate interaction proteins were identified using CompPASS, an automated MS/MS data-processing component, a protein function/annotation component, and an interaction network analysis component adapted to aid in the identification of interacting proteins that are associated with multiple baits in a network. Interactors were scored using the D score which incorporates the uniqueness, the abundance of the interactor (TSC), and the reproducibility of the interaction to assign a score to each protein within each IP (the same protein in two different IPs may have distinct D scores since its TSC and reproducibility could differ). In this way, the highest scores are given to proteins in each IP that are found rarely, found in duplicate runs, and have high TSCs-all characteristics of proteins that would be considered candidate interactors. A global D score threshold (DT) is determined and all raw D scores (DR) are normalized to this value, producing DN scores. For further details, see PMID: 19615732.
imex curation
Only protein-protein interactions
-

Interaction

Accession: EBI-3257986

Name: becn1-abcb7

Description: -

Type: physical association

Interaction type: physical association
Accession: EBI-1813147

Name: physical association

Description: physical association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0915
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Interaction between molecules within the same physical complex. Often identified under conditions which suggest that the molecules are in close proximity but not necessarily in direct contact with each other.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
Table S3

Participants (24)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
pp12pp
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
pp12pp
1
EBI-949378
 logo
Coiled-coil myosin-like BCL2-interacting protein
Protein GT197
BECN1

[+1]
Beclin-1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Beclin-1

Participant: Beclin-1

Accession: EBI-3259372

Name: EBI-949378

P
Participant: Beclin-1

Participant: Beclin-1

Accession: EBI-3259372

Name: EBI-949378

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Beclin-1

Participant: Beclin-1

Accession: EBI-3259372

Name: EBI-949378

Stoichiometry: 0.0

F
Participant: Beclin-1

Participant: Beclin-1

Accession: EBI-3259372

Name: EBI-949378

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
n terminal region
  • n-n
  • A
    Feature: EBI-3259374

    Feature: n terminal region

    Accession: EBI-3259374

    Name: n terminal region


    C
    Participant: Beclin-1

    Participant: Beclin-1

    Accession: EBI-3259372

    Name: EBI-949378

    Confidences:

    Type
    Value
    No records found.

    2
    EBI-922818
     logo
    Nup107-160 subcomplex subunit SEH1
    SEH1L
    SEC13L

    [+3]
    Nucleoporin SEH1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Nucleoporin SEH1

    Participant: Nucleoporin SEH1

    Accession: EBI-3258092

    Name: EBI-922818

    P
    Participant: Nucleoporin SEH1

    Participant: Nucleoporin SEH1

    Accession: EBI-3258092

    Name: EBI-922818

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Nucleoporin SEH1

    Participant: Nucleoporin SEH1

    Accession: EBI-3258092

    Name: EBI-922818

    Stoichiometry: 0.0

    F
    Participant: Nucleoporin SEH1

    Participant: Nucleoporin SEH1

    Accession: EBI-3258092

    Name: EBI-922818

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Nucleoporin SEH1

    Participant: Nucleoporin SEH1

    Accession: EBI-3258092

    Name: EBI-922818

    Confidences:

    Type
    Value
    High
    2.12
    p-Value=0 and Normalised Weighted D-Score =2.12
    0

    3
    EBI-948993
     logo
    G1 to S phase transition protein 1 homolog
    GSPT1
    ERF3A
    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Accession: EBI-3258096

    Name: EBI-948993

    P
    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Accession: EBI-3258096

    Name: EBI-948993

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Accession: EBI-3258096

    Name: EBI-948993

    Stoichiometry: 0.0

    F
    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Accession: EBI-3258096

    Name: EBI-948993

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Participant: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    Accession: EBI-3258096

    Name: EBI-948993

    Confidences:

    Type
    Value
    High
    2.79
    0
    p-Value=0 and Normalised Weighted D-Score =2.79

    4
    EBI-352053
     logo
    PRKDC
    HYRC
    HYRC1

    [+2]
    DNA-dependent protein kinase catalytic subunit
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DNA-dependent protein kinase catalytic subunit

    Participant: DNA-dependent protein kinase catalytic subunit

    Accession: EBI-3258200

    Name: EBI-352053

    P
    Participant: DNA-dependent protein kinase catalytic subunit

    Participant: DNA-dependent protein kinase catalytic subunit

    Accession: EBI-3258200

    Name: EBI-352053

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DNA-dependent protein kinase catalytic subunit

    Participant: DNA-dependent protein kinase catalytic subunit

    Accession: EBI-3258200

    Name: EBI-352053

    Stoichiometry: 0.0

    F
    Participant: DNA-dependent protein kinase catalytic subunit

    Participant: DNA-dependent protein kinase catalytic subunit

    Accession: EBI-3258200

    Name: EBI-352053

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DNA-dependent protein kinase catalytic subunit

    Participant: DNA-dependent protein kinase catalytic subunit

    Accession: EBI-3258200

    Name: EBI-352053

    Confidences:

    Type
    Value
    High
    1.16
    0
    p-Value=0 and Normalised Weighted D-Score =1.16

    5
    EBI-2690371
     logo
    KIAA0831
    Autophagy-related protein 14-like protein
    ATG14

    [+1]
    Beclin 1-associated autophagy-related key regulator
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Beclin 1-associated autophagy-related key regulator

    Participant: Beclin 1-associated autophagy-related key regulator

    Accession: EBI-3258272

    Name: EBI-2690371

    P
    Participant: Beclin 1-associated autophagy-related key regulator

    Participant: Beclin 1-associated autophagy-related key regulator

    Accession: EBI-3258272

    Name: EBI-2690371

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Beclin 1-associated autophagy-related key regulator

    Participant: Beclin 1-associated autophagy-related key regulator

    Accession: EBI-3258272

    Name: EBI-2690371

    Stoichiometry: 0.0

    F
    Participant: Beclin 1-associated autophagy-related key regulator

    Participant: Beclin 1-associated autophagy-related key regulator

    Accession: EBI-3258272

    Name: EBI-2690371

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Beclin 1-associated autophagy-related key regulator

    Participant: Beclin 1-associated autophagy-related key regulator

    Accession: EBI-3258272

    Name: EBI-2690371

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =15.15
    High
    15.15
    0

    6
    EBI-358755
     logo
    AFG3L2
    Paraplegin-like protein
    AFG3-like protein 2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: AFG3-like protein 2

    Participant: AFG3-like protein 2

    Accession: EBI-3258276

    Name: EBI-358755

    P
    Participant: AFG3-like protein 2

    Participant: AFG3-like protein 2

    Accession: EBI-3258276

    Name: EBI-358755

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: AFG3-like protein 2

    Participant: AFG3-like protein 2

    Accession: EBI-3258276

    Name: EBI-358755

    Stoichiometry: 0.0

    F
    Participant: AFG3-like protein 2

    Participant: AFG3-like protein 2

    Accession: EBI-3258276

    Name: EBI-358755

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: AFG3-like protein 2

    Participant: AFG3-like protein 2

    Accession: EBI-3258276

    Name: EBI-358755

    Confidences:

    Type
    Value
    High
    2.17
    p-Value=0 and Normalised Weighted D-Score =2.17
    0

    7
    EBI-722211
     logo
    Activator interaction domain-containing protein 2
    PP642
    UNQ6127/PRO20092

    [+2]
    Prostate tumor-overexpressed gene 1 protein
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Prostate tumor-overexpressed gene 1 protein

    Participant: Prostate tumor-overexpressed gene 1 protein

    Accession: EBI-3258328

    Name: EBI-722211

    P
    Participant: Prostate tumor-overexpressed gene 1 protein

    Participant: Prostate tumor-overexpressed gene 1 protein

    Accession: EBI-3258328

    Name: EBI-722211

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Prostate tumor-overexpressed gene 1 protein

    Participant: Prostate tumor-overexpressed gene 1 protein

    Accession: EBI-3258328

    Name: EBI-722211

    Stoichiometry: 0.0

    F
    Participant: Prostate tumor-overexpressed gene 1 protein

    Participant: Prostate tumor-overexpressed gene 1 protein

    Accession: EBI-3258328

    Name: EBI-722211

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Prostate tumor-overexpressed gene 1 protein

    Participant: Prostate tumor-overexpressed gene 1 protein

    Accession: EBI-3258328

    Name: EBI-722211

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =17.49
    High
    17.49
    0

    8
    EBI-3229670
     logo
    TRABD
    TTG2
    Protein TTG2

    [+1]
    TraB domain-containing protein
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: TraB domain-containing protein

    Participant: TraB domain-containing protein

    Accession: EBI-3258384

    Name: EBI-3229670

    P
    Participant: TraB domain-containing protein

    Participant: TraB domain-containing protein

    Accession: EBI-3258384

    Name: EBI-3229670

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: TraB domain-containing protein

    Participant: TraB domain-containing protein

    Accession: EBI-3258384

    Name: EBI-3229670

    Stoichiometry: 0.0

    F
    Participant: TraB domain-containing protein

    Participant: TraB domain-containing protein

    Accession: EBI-3258384

    Name: EBI-3229670

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: TraB domain-containing protein

    Participant: TraB domain-containing protein

    Accession: EBI-3258384

    Name: EBI-3229670

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =8.75
    High
    8.75
    0

    9
    EBI-3258000
     logo
    Cell migration-inducing protein 23
    TBC1D7
    TBC7

    [+1]
    TBC1 domain family member 7
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: TBC1 domain family member 7

    Participant: TBC1 domain family member 7

    Accession: EBI-3258388

    Name: EBI-3258000

    P
    Participant: TBC1 domain family member 7

    Participant: TBC1 domain family member 7

    Accession: EBI-3258388

    Name: EBI-3258000

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: TBC1 domain family member 7

    Participant: TBC1 domain family member 7

    Accession: EBI-3258388

    Name: EBI-3258000

    Stoichiometry: 0.0

    F
    Participant: TBC1 domain family member 7

    Participant: TBC1 domain family member 7

    Accession: EBI-3258388

    Name: EBI-3258000

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: TBC1 domain family member 7

    Participant: TBC1 domain family member 7

    Accession: EBI-3258388

    Name: EBI-3258000

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =17.49
    High
    17.49
    0

    10
    EBI-1047085
     logo
    TSC1
    KIAA0243
    Tuberous sclerosis 1 protein

    [+1]
    Hamartin
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Hamartin

    Participant: Hamartin

    Accession: EBI-3258400

    Name: EBI-1047085

    P
    Participant: Hamartin

    Participant: Hamartin

    Accession: EBI-3258400

    Name: EBI-1047085

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Hamartin

    Participant: Hamartin

    Accession: EBI-3258400

    Name: EBI-1047085

    Stoichiometry: 0.0

    F
    Participant: Hamartin

    Participant: Hamartin

    Accession: EBI-3258400

    Name: EBI-1047085

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Hamartin

    Participant: Hamartin

    Accession: EBI-3258400

    Name: EBI-1047085

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =34.99
    High
    34.99
    0

    11
    EBI-2362014
     logo
    NRBF2
    COPR
    Comodulator of PPAR and RXR
    Nuclear receptor-binding factor 2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Nuclear receptor-binding factor 2

    Participant: Nuclear receptor-binding factor 2

    Accession: EBI-3258440

    Name: EBI-2362014

    P
    Participant: Nuclear receptor-binding factor 2

    Participant: Nuclear receptor-binding factor 2

    Accession: EBI-3258440

    Name: EBI-2362014

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Nuclear receptor-binding factor 2

    Participant: Nuclear receptor-binding factor 2

    Accession: EBI-3258440

    Name: EBI-2362014

    Stoichiometry: 0.0

    F
    Participant: Nuclear receptor-binding factor 2

    Participant: Nuclear receptor-binding factor 2

    Accession: EBI-3258440

    Name: EBI-2362014

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Nuclear receptor-binding factor 2

    Participant: Nuclear receptor-binding factor 2

    Accession: EBI-3258440

    Name: EBI-2362014

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =7.25
    High
    7.25
    0

    12
    EBI-1056470
     logo
    PIK3C3
    Phosphoinositide-3-kinase class 3
    Phosphatidylinositol 3-kinase p100 subunit

    [+2]
    Phosphatidylinositol 3-kinase catalytic subunit type 3
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Accession: EBI-3258548

    Name: EBI-1056470

    P
    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Accession: EBI-3258548

    Name: EBI-1056470

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Accession: EBI-3258548

    Name: EBI-1056470

    Stoichiometry: 0.0

    F
    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Accession: EBI-3258548

    Name: EBI-1056470

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Participant: Phosphatidylinositol 3-kinase catalytic subunit type 3

    Accession: EBI-3258548

    Name: EBI-1056470

    Confidences:

    Type
    Value
    High
    25.72
    0
    p-Value=0 and Normalised Weighted D-Score =25.72

    13
    EBI-80718
     logo
    SMC3
    BAM
    SMC3L1

    [+5]
    Structural maintenance of chromosomes protein 3
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Structural maintenance of chromosomes protein 3

    Participant: Structural maintenance of chromosomes protein 3

    Accession: EBI-3258600

    Name: EBI-80718

    P
    Participant: Structural maintenance of chromosomes protein 3

    Participant: Structural maintenance of chromosomes protein 3

    Accession: EBI-3258600

    Name: EBI-80718

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Structural maintenance of chromosomes protein 3

    Participant: Structural maintenance of chromosomes protein 3

    Accession: EBI-3258600

    Name: EBI-80718

    Stoichiometry: 0.0

    F
    Participant: Structural maintenance of chromosomes protein 3

    Participant: Structural maintenance of chromosomes protein 3

    Accession: EBI-3258600

    Name: EBI-80718

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Structural maintenance of chromosomes protein 3

    Participant: Structural maintenance of chromosomes protein 3

    Accession: EBI-3258600

    Name: EBI-80718

    Confidences:

    Type
    Value
    High
    1.03
    0.00000000565
    p-Value=0.00000000565 and Normalised Weighted D-Score =1.03

    14
    EBI-2512975
     logo
    AMBRA1
    KIAA1736
    Activating molecule in BECN1-regulated autophagy protein 1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Accession: EBI-3258632

    Name: EBI-2512975

    P
    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Accession: EBI-3258632

    Name: EBI-2512975

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Accession: EBI-3258632

    Name: EBI-2512975

    Stoichiometry: 0.0

    F
    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Accession: EBI-3258632

    Name: EBI-2512975

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Participant: Activating molecule in BECN1-regulated autophagy protein 1

    Accession: EBI-3258632

    Name: EBI-2512975

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =6.11
    High
    6.11
    0

    15
    EBI-1052237
     logo
    Solute carrier family 27 member 4
    SLC27A4
    ACSVL4

    [+1]
    Long-chain fatty acid transport protein 4
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Long-chain fatty acid transport protein 4

    Participant: Long-chain fatty acid transport protein 4

    Accession: EBI-3258696

    Name: EBI-1052237

    P
    Participant: Long-chain fatty acid transport protein 4

    Participant: Long-chain fatty acid transport protein 4

    Accession: EBI-3258696

    Name: EBI-1052237

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Long-chain fatty acid transport protein 4

    Participant: Long-chain fatty acid transport protein 4

    Accession: EBI-3258696

    Name: EBI-1052237

    Stoichiometry: 0.0

    F
    Participant: Long-chain fatty acid transport protein 4

    Participant: Long-chain fatty acid transport protein 4

    Accession: EBI-3258696

    Name: EBI-1052237

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Long-chain fatty acid transport protein 4

    Participant: Long-chain fatty acid transport protein 4

    Accession: EBI-3258696

    Name: EBI-1052237

    Confidences:

    Type
    Value
    High
    24.74
    0
    p-Value=0 and Normalised Weighted D-Score =24.74

    16
    EBI-948630
     logo
    DAZ-interacting protein 3
    RNA-binding ubiquitin ligase of 138 kDa
    DZIP3

    [+2]
    E3 ubiquitin-protein ligase DZIP3
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: E3 ubiquitin-protein ligase DZIP3

    Participant: E3 ubiquitin-protein ligase DZIP3

    Accession: EBI-3259012

    Name: EBI-948630

    P
    Participant: E3 ubiquitin-protein ligase DZIP3

    Participant: E3 ubiquitin-protein ligase DZIP3

    Accession: EBI-3259012

    Name: EBI-948630

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: E3 ubiquitin-protein ligase DZIP3

    Participant: E3 ubiquitin-protein ligase DZIP3

    Accession: EBI-3259012

    Name: EBI-948630

    Stoichiometry: 0.0

    F
    Participant: E3 ubiquitin-protein ligase DZIP3

    Participant: E3 ubiquitin-protein ligase DZIP3

    Accession: EBI-3259012

    Name: EBI-948630

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: E3 ubiquitin-protein ligase DZIP3

    Participant: E3 ubiquitin-protein ligase DZIP3

    Accession: EBI-3259012

    Name: EBI-948630

    Confidences:

    Type
    Value
    p-Value=0 and Normalised Weighted D-Score =17.49
    High
    17.49
    0

    17
    EBI-1046979
     logo
    PI3-kinase p150 subunit
    Phosphoinositide 3-kinase adaptor protein
    PIK3R4

    [+1]
    Phosphoinositide 3-kinase regulatory subunit 4
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Accession: EBI-3259108

    Name: EBI-1046979

    P
    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Accession: EBI-3259108

    Name: EBI-1046979

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Accession: EBI-3259108

    Name: EBI-1046979

    Stoichiometry: 0.0

    F
    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Accession: EBI-3259108

    Name: EBI-1046979

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Participant: Phosphoinositide 3-kinase regulatory subunit 4

    Accession: EBI-3259108

    Name: EBI-1046979

    Confidences:

    Type
    Value
    High
    25.03
    0
    p-Value=0 and Normalised Weighted D-Score =25.03

    18
    EBI-1001132
     logo
    ZW10-interacting protein 1
    ZWINT
    ZW10 interactor
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: ZW10 interactor

    Participant: ZW10 interactor

    Accession: EBI-3259168

    Name: EBI-1001132

    P
    Participant: ZW10 interactor

    Participant: ZW10 interactor

    Accession: EBI-3259168

    Name: EBI-1001132

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: ZW10 interactor

    Participant: ZW10 interactor

    Accession: EBI-3259168

    Name: EBI-1001132

    Stoichiometry: 0.0

    F
    Participant: ZW10 interactor

    Participant: ZW10 interactor

    Accession: EBI-3259168

    Name: EBI-1001132

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: ZW10 interactor

    Participant: ZW10 interactor

    Accession: EBI-3259168

    Name: EBI-1001132

    Confidences:

    Type
    Value
    p-Value=0.00000000565 and Normalised Weighted D-Score =8.11
    High
    8.11
    0.00000000565

    19
    EBI-2952704
     logo
    UVRAG
    p63
    UV radiation resistance-associated gene protein
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: UV radiation resistance-associated gene protein

    Participant: UV radiation resistance-associated gene protein

    Accession: EBI-3259172

    Name: EBI-2952704

    P
    Participant: UV radiation resistance-associated gene protein

    Participant: UV radiation resistance-associated gene protein

    Accession: EBI-3259172

    Name: EBI-2952704

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: UV radiation resistance-associated gene protein

    Participant: UV radiation resistance-associated gene protein

    Accession: EBI-3259172

    Name: EBI-2952704

    Stoichiometry: 0.0

    F
    Participant: UV radiation resistance-associated gene protein

    Participant: UV radiation resistance-associated gene protein

    Accession: EBI-3259172

    Name: EBI-2952704

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: UV radiation resistance-associated gene protein

    Participant: UV radiation resistance-associated gene protein

    Accession: EBI-3259172

    Name: EBI-2952704

    Confidences:

    Type
    Value
    High
    23.14
    0
    p-Value=0 and Normalised Weighted D-Score =23.14

    20
    EBI-949378
     logo
    Coiled-coil myosin-like BCL2-interacting protein
    Protein GT197
    BECN1

    [+1]
    Beclin-1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Beclin-1

    Participant: Beclin-1

    Accession: EBI-3259264

    Name: EBI-949378

    P
    Participant: Beclin-1

    Participant: Beclin-1

    Accession: EBI-3259264

    Name: EBI-949378

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Beclin-1

    Participant: Beclin-1

    Accession: EBI-3259264

    Name: EBI-949378

    Stoichiometry: 0.0

    F
    Participant: Beclin-1

    Participant: Beclin-1

    Accession: EBI-3259264

    Name: EBI-949378

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Beclin-1

    Participant: Beclin-1

    Accession: EBI-3259264

    Name: EBI-949378

    Confidences:

    Type
    Value
    High
    12.46
    0
    p-Value=0 and Normalised Weighted D-Score =12.46


    Graphical Representation of Experimental Features