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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 16554755

Journal: Nature (0028-0836)

Year of Publication: 2006

Title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.

Author List: Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O Shea E, Weissman JS, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF

Cross References:

Experiment (547 interactions)

Accession: EBI-8184090

Name: krogan-2006-3

Host organism:

Organism:

Accession: EBI-6918234

Name: in silico

Description: -

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Interaction Detection Method: inferred by author

Interaction detection method: inferred by author
Accession: EBI-608504

Name: inferred by author

Description: inferred by author

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0363
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Evidence based on the author of a paper assumption, either when the complete experimental support is not available or when the results are extended by homology to closely related orthologues sequences.


Participant Identification Method: predetermined

Participant identification method: predetermined
Accession: EBI-1465

Name: predetermined

Description: predetermined participant

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0396
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule whose sequence identity is not checked and has been assumed from external or previous experimental evidence(s).


Cross References:

Annotations:

Topic
Text
The authors generated a large dataset of interactions using the tandem affinity purification technology (TAP). The prey proteins were identified in parallel experiments by MALDI-TOF/MS and LC-MS/MS analysis. A core dataset of binary interaction was generated by a machine learning procedure assigning a confidence score to each interactions. All the interactions belonging to the core dataset display a confidence score higher than 0.273. In MINT are collected only the interactions belonging to the core dataset. For each interaction the confidence score is reported. For each protein identified by MALDI-TOF/MS the numbers of peptides detected are reported; the Z-score provides confidence measure for the identification of the protein. For each protein identified by LC-MS/MS numbers of peptides detected are reported; the probability value provides confidence measure for the identification of the protein. All the original datasets provided by the authors are available at the following URL : ftp://mint.bio.uniroma2.it/pub/data/krogan-2006
-
imex curation
Only protein-protein interactions
-

Interaction

Accession: EBI-8226241

Name: cbc2-kap95-4

Description: krogan-2006 complex_36

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0914
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
homomint
mint

Participants (13)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
1
EBI-33556
 logo
20 kDa nuclear cap-binding protein
NCBP 20 kDa subunit
CBC2

[+4]
Nuclear cap-binding protein subunit 2
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Nuclear cap-binding protein subunit 2

Participant: Nuclear cap-binding protein subunit 2

Accession: EBI-8226246

Name: EBI-33556

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Nuclear cap-binding protein subunit 2

Participant: Nuclear cap-binding protein subunit 2

Accession: EBI-8226246

Name: EBI-33556

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Nuclear cap-binding protein subunit 2

Participant: Nuclear cap-binding protein subunit 2

Accession: EBI-8226246

Name: EBI-33556

Stoichiometry: 1.0

F
Participant: Nuclear cap-binding protein subunit 2

Participant: Nuclear cap-binding protein subunit 2

Accession: EBI-8226246

Name: EBI-33556

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Nuclear cap-binding protein subunit 2

Participant: Nuclear cap-binding protein subunit 2

Accession: EBI-8226246

Name: EBI-33556

Confidences:

Type
Value
No records found.

2
EBI-5254
 logo
PCT1
CCT
CCT1

[+4]
Choline-phosphate cytidylyltransferase
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Choline-phosphate cytidylyltransferase

Participant: Choline-phosphate cytidylyltransferase

Accession: EBI-8226249

Name: EBI-5254

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Choline-phosphate cytidylyltransferase

Participant: Choline-phosphate cytidylyltransferase

Accession: EBI-8226249

Name: EBI-5254

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Choline-phosphate cytidylyltransferase

Participant: Choline-phosphate cytidylyltransferase

Accession: EBI-8226249

Name: EBI-5254

Stoichiometry: 1.0

F
Participant: Choline-phosphate cytidylyltransferase

Participant: Choline-phosphate cytidylyltransferase

Accession: EBI-8226249

Name: EBI-5254

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Choline-phosphate cytidylyltransferase

Participant: Choline-phosphate cytidylyltransferase

Accession: EBI-8226249

Name: EBI-5254

Confidences:

Type
Value
No records found.

3
EBI-745
 logo
STO1
CBC1
SUT1

[+9]
Nuclear cap-binding protein complex subunit 1
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Nuclear cap-binding protein complex subunit 1

Participant: Nuclear cap-binding protein complex subunit 1

Accession: EBI-8226252

Name: EBI-745

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Nuclear cap-binding protein complex subunit 1

Participant: Nuclear cap-binding protein complex subunit 1

Accession: EBI-8226252

Name: EBI-745

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Nuclear cap-binding protein complex subunit 1

Participant: Nuclear cap-binding protein complex subunit 1

Accession: EBI-8226252

Name: EBI-745

Stoichiometry: 1.0

F
Participant: Nuclear cap-binding protein complex subunit 1

Participant: Nuclear cap-binding protein complex subunit 1

Accession: EBI-8226252

Name: EBI-745

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Nuclear cap-binding protein complex subunit 1

Participant: Nuclear cap-binding protein complex subunit 1

Accession: EBI-8226252

Name: EBI-745

Confidences:

Type
Value
No records found.

4
EBI-17843
 logo
RAD53
MEC2
SAD1

[+5]
Serine/threonine-protein kinase RAD53
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Serine/threonine-protein kinase RAD53

Participant: Serine/threonine-protein kinase RAD53

Accession: EBI-8226255

Name: EBI-17843

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Serine/threonine-protein kinase RAD53

Participant: Serine/threonine-protein kinase RAD53

Accession: EBI-8226255

Name: EBI-17843

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Serine/threonine-protein kinase RAD53

Participant: Serine/threonine-protein kinase RAD53

Accession: EBI-8226255

Name: EBI-17843

Stoichiometry: 1.0

F
Participant: Serine/threonine-protein kinase RAD53

Participant: Serine/threonine-protein kinase RAD53

Accession: EBI-8226255

Name: EBI-17843

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Serine/threonine-protein kinase RAD53

Participant: Serine/threonine-protein kinase RAD53

Accession: EBI-8226255

Name: EBI-17843

Confidences:

Type
Value
No records found.

5
EBI-27015
 logo
YRA2
YKL214C
RNA annealing protein YRA2
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: RNA annealing protein YRA2

Participant: RNA annealing protein YRA2

Accession: EBI-8226258

Name: EBI-27015

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: RNA annealing protein YRA2

Participant: RNA annealing protein YRA2

Accession: EBI-8226258

Name: EBI-27015

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: RNA annealing protein YRA2

Participant: RNA annealing protein YRA2

Accession: EBI-8226258

Name: EBI-27015

Stoichiometry: 1.0

F
Participant: RNA annealing protein YRA2

Participant: RNA annealing protein YRA2

Accession: EBI-8226258

Name: EBI-27015

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: RNA annealing protein YRA2

Participant: RNA annealing protein YRA2

Accession: EBI-8226258

Name: EBI-27015

Confidences:

Type
Value
No records found.

6
EBI-9145
 logo
KAP95
YLR347C
L8300.15

[+3]
Importin subunit beta-1
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Importin subunit beta-1

Participant: Importin subunit beta-1

Accession: EBI-8226261

Name: EBI-9145

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Importin subunit beta-1

Participant: Importin subunit beta-1

Accession: EBI-8226261

Name: EBI-9145

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Importin subunit beta-1

Participant: Importin subunit beta-1

Accession: EBI-8226261

Name: EBI-9145

Stoichiometry: 1.0

F
Participant: Importin subunit beta-1

Participant: Importin subunit beta-1

Accession: EBI-8226261

Name: EBI-9145

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Importin subunit beta-1

Participant: Importin subunit beta-1

Accession: EBI-8226261

Name: EBI-9145

Confidences:

Type
Value
No records found.

7
EBI-25492
 logo
YJR041C
J1622
Unhealthy ribosome biogenesis protein 2

[+2]
Nucleolar pre-ribosomal-associated protein 2
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Nucleolar pre-ribosomal-associated protein 2

Participant: Nucleolar pre-ribosomal-associated protein 2

Accession: EBI-8226264

Name: EBI-25492

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Nucleolar pre-ribosomal-associated protein 2

Participant: Nucleolar pre-ribosomal-associated protein 2

Accession: EBI-8226264

Name: EBI-25492

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Nucleolar pre-ribosomal-associated protein 2

Participant: Nucleolar pre-ribosomal-associated protein 2

Accession: EBI-8226264

Name: EBI-25492

Stoichiometry: 1.0

F
Participant: Nucleolar pre-ribosomal-associated protein 2

Participant: Nucleolar pre-ribosomal-associated protein 2

Accession: EBI-8226264

Name: EBI-25492

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Nucleolar pre-ribosomal-associated protein 2

Participant: Nucleolar pre-ribosomal-associated protein 2

Accession: EBI-8226264

Name: EBI-25492

Confidences:

Type
Value
No records found.

8
EBI-1797
 logo
SRP1
KAP60
YNL189W

[+4]
Importin subunit alpha
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Importin subunit alpha

Participant: Importin subunit alpha

Accession: EBI-8226267

Name: EBI-1797

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Importin subunit alpha

Participant: Importin subunit alpha

Accession: EBI-8226267

Name: EBI-1797

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Importin subunit alpha

Participant: Importin subunit alpha

Accession: EBI-8226267

Name: EBI-1797

Stoichiometry: 1.0

F
Participant: Importin subunit alpha

Participant: Importin subunit alpha

Accession: EBI-8226267

Name: EBI-1797

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Importin subunit alpha

Participant: Importin subunit alpha

Accession: EBI-8226267

Name: EBI-1797

Confidences:

Type
Value
No records found.

9
EBI-12401
 logo
NUP2
YLR335W
L8300.9

[+2]
Nucleoporin NUP2
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Nucleoporin NUP2

Participant: Nucleoporin NUP2

Accession: EBI-8226270

Name: EBI-12401

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Nucleoporin NUP2

Participant: Nucleoporin NUP2

Accession: EBI-8226270

Name: EBI-12401

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Nucleoporin NUP2

Participant: Nucleoporin NUP2

Accession: EBI-8226270

Name: EBI-12401

Stoichiometry: 1.0

F
Participant: Nucleoporin NUP2

Participant: Nucleoporin NUP2

Accession: EBI-8226270

Name: EBI-12401

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Nucleoporin NUP2

Participant: Nucleoporin NUP2

Accession: EBI-8226270

Name: EBI-12401

Confidences:

Type
Value
No records found.

10
EBI-20050
 logo
ULP1
LPB11C
YPL020C
Ubiquitin-like-specific protease 1
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Ubiquitin-like-specific protease 1

Participant: Ubiquitin-like-specific protease 1

Accession: EBI-8226273

Name: EBI-20050

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Ubiquitin-like-specific protease 1

Participant: Ubiquitin-like-specific protease 1

Accession: EBI-8226273

Name: EBI-20050

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Ubiquitin-like-specific protease 1

Participant: Ubiquitin-like-specific protease 1

Accession: EBI-8226273

Name: EBI-20050

Stoichiometry: 1.0

F
Participant: Ubiquitin-like-specific protease 1

Participant: Ubiquitin-like-specific protease 1

Accession: EBI-8226273

Name: EBI-20050

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Ubiquitin-like-specific protease 1

Participant: Ubiquitin-like-specific protease 1

Accession: EBI-8226273

Name: EBI-20050

Confidences:

Type
Value
No records found.

11
EBI-12494
 logo
YM9958.02
YML060W
OGG1
N-glycosylase/DNA lyase
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: N-glycosylase/DNA lyase

Participant: N-glycosylase/DNA lyase

Accession: EBI-8226276

Name: EBI-12494

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: N-glycosylase/DNA lyase

Participant: N-glycosylase/DNA lyase

Accession: EBI-8226276

Name: EBI-12494

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: N-glycosylase/DNA lyase

Participant: N-glycosylase/DNA lyase

Accession: EBI-8226276

Name: EBI-12494

Stoichiometry: 1.0

F
Participant: N-glycosylase/DNA lyase

Participant: N-glycosylase/DNA lyase

Accession: EBI-8226276

Name: EBI-12494

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: N-glycosylase/DNA lyase

Participant: N-glycosylase/DNA lyase

Accession: EBI-8226276

Name: EBI-12494

Confidences:

Type
Value
No records found.

12
EBI-12392
 logo
NUP1
YOR098C
YOR3182C

[+1]
Nucleoporin NUP1
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Nucleoporin NUP1

Participant: Nucleoporin NUP1

Accession: EBI-8226279

Name: EBI-12392

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Nucleoporin NUP1

Participant: Nucleoporin NUP1

Accession: EBI-8226279

Name: EBI-12392

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Nucleoporin NUP1

Participant: Nucleoporin NUP1

Accession: EBI-8226279

Name: EBI-12392

Stoichiometry: 1.0

F
Participant: Nucleoporin NUP1

Participant: Nucleoporin NUP1

Accession: EBI-8226279

Name: EBI-12392

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Nucleoporin NUP1

Participant: Nucleoporin NUP1

Accession: EBI-8226279

Name: EBI-12392

Confidences:

Type
Value
No records found.

13
EBI-20731
 logo
YAR002W
NUP60
FUN17

[+1]
Nucleoporin NUP60
Saccharomyces cerevisiae
Organism Details

Accession: EBI-2935809

Name: yeast

Description: Saccharomyces cerevisiae

Cross References:

Database
Identifier
Secondary identifier
Qualifier
baker's yeast

Expressed In Details

Accession:

Name:

-
neutral component
Experimental role: neutral component
Accession: EBI-55

Name: neutral component

Description: neutral component

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0497
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule role in an experimental setting that does not have an embedded asymmetry.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Nucleoporin NUP60

Participant: Nucleoporin NUP60

Accession: EBI-8226282

Name: EBI-20731

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Stoichiometry: 1.0

P
Participant: Nucleoporin NUP60

Participant: Nucleoporin NUP60

Accession: EBI-8226282

Name: EBI-20731

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Nucleoporin NUP60

Participant: Nucleoporin NUP60

Accession: EBI-8226282

Name: EBI-20731

Stoichiometry: 1.0

F
Participant: Nucleoporin NUP60

Participant: Nucleoporin NUP60

Accession: EBI-8226282

Name: EBI-20731

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Nucleoporin NUP60

Participant: Nucleoporin NUP60

Accession: EBI-8226282

Name: EBI-20731

Confidences:

Type
Value
No records found.