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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 22682247

Journal: Cell (0092-8674)

Year of Publication: 2012

Title: Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex.

Author List: Li V.S., Ng S.S., Boersema P.J., Low T.Y., Karthaus W.R., Gerlach J.P., Mohammed S., Heck A.J., Maurice M.M., Mahmoudi T., Clevers H.

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Experiment (1 interaction)

Accession: EBI-6169717

Name: li-2012-5

Host organism: Homo sapiens

Organism: Homo sapiens

Accession: EBI-6169667

Name: human-ls147t

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Interaction Detection Method: anti bait coip

Interaction detection method: anti bait coip
Accession: EBI-976

Name: anti bait coip

Description: anti bait coimmunoprecipitation

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0006
-
identity
pubmed
7708014
-
primary-reference


Annotations:
Topic
Text
definition
A specific antibody for the molecule of interest (bait) is available, this is used to generate a high affinity resin to capture the endogenous bait present in a sample.


Participant Identification Method: sequence tag

Participant identification method: sequence tag
Accession: EBI-81

Name: sequence tag

Description: sequence tag identification

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0102
-
identity
pubmed
10967324
-
primary-reference
pubmed
11752590
-
primary-reference
pubmed
11805837
-
primary-reference


Annotations:
Topic
Text
definition
This approach leads to protein identification by combining mass measurement and short amino acid sequence information obtained by tandem mass spectrometry. This information is then used to automatically find the best match in a sequence database. A mixture of peptides derived from a protease digestion is analysed by nanoelectrospray LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometer or nanoESI MS/MS) mass spectrometry. Electrospray mass spectrometry cannot be applied to dilute samples and is affected by high salt. As a consequence peptides, normally extracted from acrylamide gels by in situ proteolysis, are desalted and concentrated on a microcolumn followed by elution into a capillary used for nanoelectrospray tandem mass spectrometry. A first mass spectrum (Normal mass spectrum or Q1 mass spectrum) gives information about the masses of all the peptides. Peptides observed in the normal mass spectrum are isolated in turn and dissociated into fragments by collision with gas molecules within the mass spectrometer. Some of the fragments obtained from a peptide constitute a nested set, differing by one amino acid, and the mass difference between them allows assignment of a partial sequence. The masses of the fragments define the position of the partial sequence in the peptide. Together with the cleavage specificity of the protease used to cleave the protein, and mass information such sequence tag provides much higher search specificity to match the a database entry. The procedure is repeated with several peptides from the digest, resulting in multiple identifications of the same protein or identification of several proteins from the peptide mixture. Unknown proteins can easily be identified by using the high specificity of the peptide sequence tag for searches in most sequence databases including EST or genome databases.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
h.clevers@hubrecht.eu, t.mahmoudi@erasmusmc.nl
imex curation
Only protein-protein interactions
-
Time after Wnt stimulation

Interaction

Accession: EBI-6169727

Name: axin1-apc-6

Description: -

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
pubmed
14755292
-
primary-reference
psi-mi
MI:0914
-
identity


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Supp. Table 1
GSK3 alpha/beta was also identified but could not be ascribed to a single gene product.

Participants (10)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
1
EBI-710484
 logo
AXIN1
AXIN
Axis inhibition protein 1
Axin-1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Axin-1

Participant: Axin-1

Accession: EBI-6169743

Name: EBI-710484

P
Participant: Axin-1

Participant: Axin-1

Accession: EBI-6169743

Name: EBI-710484

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Axin-1

Participant: Axin-1

Accession: EBI-6169743

Name: EBI-710484

Stoichiometry: 0.0

F
Participant: Axin-1

Participant: Axin-1

Accession: EBI-6169743

Name: EBI-710484

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Axin-1

Participant: Axin-1

Accession: EBI-6169743

Name: EBI-710484

Confidences:

Type
Value
No records found.

2
EBI-749343
 logo
CSNK1E
Casein kinase I isoform epsilon
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Casein kinase I isoform epsilon

Participant: Casein kinase I isoform epsilon

Accession: EBI-6169730

Name: EBI-749343

P
Participant: Casein kinase I isoform epsilon

Participant: Casein kinase I isoform epsilon

Accession: EBI-6169730

Name: EBI-749343

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Casein kinase I isoform epsilon

Participant: Casein kinase I isoform epsilon

Accession: EBI-6169730

Name: EBI-749343

Stoichiometry: 0.0

F
Participant: Casein kinase I isoform epsilon

Participant: Casein kinase I isoform epsilon

Accession: EBI-6169730

Name: EBI-749343

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Casein kinase I isoform epsilon

Participant: Casein kinase I isoform epsilon

Accession: EBI-6169730

Name: EBI-749343

Confidences:

Type
Value
No records found.

3
EBI-491549
 logo
CTNNB1
CTNNB
Beta-catenin

[+2]
Catenin beta-1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Catenin beta-1

Participant: Catenin beta-1

Accession: EBI-6169733

Name: EBI-491549

P
Participant: Catenin beta-1

Participant: Catenin beta-1

Accession: EBI-6169733

Name: EBI-491549

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Catenin beta-1

Participant: Catenin beta-1

Accession: EBI-6169733

Name: EBI-491549

Stoichiometry: 0.0

F
Participant: Catenin beta-1

Participant: Catenin beta-1

Accession: EBI-6169733

Name: EBI-491549

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Catenin beta-1

Participant: Catenin beta-1

Accession: EBI-6169733

Name: EBI-491549

Confidences:

Type
Value
No records found.

4
EBI-49776
 logo
MAPK/ERK kinase kinase 1
MAP3K1
MAPKKK1

[+2]
Mitogen-activated protein kinase kinase kinase 1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Mitogen-activated protein kinase kinase kinase 1

Participant: Mitogen-activated protein kinase kinase kinase 1

Accession: EBI-6169736

Name: EBI-49776

P
Participant: Mitogen-activated protein kinase kinase kinase 1

Participant: Mitogen-activated protein kinase kinase kinase 1

Accession: EBI-6169736

Name: EBI-49776

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Mitogen-activated protein kinase kinase kinase 1

Participant: Mitogen-activated protein kinase kinase kinase 1

Accession: EBI-6169736

Name: EBI-49776

Stoichiometry: 0.0

F
Participant: Mitogen-activated protein kinase kinase kinase 1

Participant: Mitogen-activated protein kinase kinase kinase 1

Accession: EBI-6169736

Name: EBI-49776

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Mitogen-activated protein kinase kinase kinase 1

Participant: Mitogen-activated protein kinase kinase kinase 1

Accession: EBI-6169736

Name: EBI-49776

Confidences:

Type
Value
No records found.

5
EBI-712311
 logo
PPP2CA
Replication protein C
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Accession: EBI-6169740

Name: EBI-712311

P
Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Accession: EBI-6169740

Name: EBI-712311

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Accession: EBI-6169740

Name: EBI-712311

Stoichiometry: 0.0

F
Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Accession: EBI-6169740

Name: EBI-712311

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Participant: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Accession: EBI-6169740

Name: EBI-712311

Confidences:

Type
Value
No records found.

6
EBI-4400025
 logo
AXIN2
Axin-like protein
Axis inhibition protein 2

[+1]
Axin-2
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Axin-2

Participant: Axin-2

Accession: EBI-6169741

Name: EBI-4400025

P
Participant: Axin-2

Participant: Axin-2

Accession: EBI-6169741

Name: EBI-4400025

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Axin-2

Participant: Axin-2

Accession: EBI-6169741

Name: EBI-4400025

Stoichiometry: 0.0

F
Participant: Axin-2

Participant: Axin-2

Accession: EBI-6169741

Name: EBI-4400025

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Axin-2

Participant: Axin-2

Accession: EBI-6169741

Name: EBI-4400025

Confidences:

Type
Value
No records found.

7
EBI-357481
 logo
Synapse-associated protein 97
hDlg
DLG1
Disks large homolog 1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Disks large homolog 1

Participant: Disks large homolog 1

Accession: EBI-6169742

Name: EBI-357481

P
Participant: Disks large homolog 1

Participant: Disks large homolog 1

Accession: EBI-6169742

Name: EBI-357481

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Disks large homolog 1

Participant: Disks large homolog 1

Accession: EBI-6169742

Name: EBI-357481

Stoichiometry: 0.0

F
Participant: Disks large homolog 1

Participant: Disks large homolog 1

Accession: EBI-6169742

Name: EBI-357481

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Disks large homolog 1

Participant: Disks large homolog 1

Accession: EBI-6169742

Name: EBI-357481

Confidences:

Type
Value
No records found.

8
EBI-1383726
 logo
CSNK1A1
CK1
Casein kinase I isoform alpha
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Casein kinase I isoform alpha

Participant: Casein kinase I isoform alpha

Accession: EBI-6169744

Name: EBI-1383726

P
Participant: Casein kinase I isoform alpha

Participant: Casein kinase I isoform alpha

Accession: EBI-6169744

Name: EBI-1383726

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Casein kinase I isoform alpha

Participant: Casein kinase I isoform alpha

Accession: EBI-6169744

Name: EBI-1383726

Stoichiometry: 0.0

F
Participant: Casein kinase I isoform alpha

Participant: Casein kinase I isoform alpha

Accession: EBI-6169744

Name: EBI-1383726

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Casein kinase I isoform alpha

Participant: Casein kinase I isoform alpha

Accession: EBI-6169744

Name: EBI-1383726

Confidences:

Type
Value
No records found.

9
EBI-727707
 logo
APC
DP2.5
Deleted in polyposis 2.5
Adenomatous polyposis coli protein
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Adenomatous polyposis coli protein

Participant: Adenomatous polyposis coli protein

Accession: EBI-6169745

Name: EBI-727707

P
Participant: Adenomatous polyposis coli protein

Participant: Adenomatous polyposis coli protein

Accession: EBI-6169745

Name: EBI-727707

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Adenomatous polyposis coli protein

Participant: Adenomatous polyposis coli protein

Accession: EBI-6169745

Name: EBI-727707

Stoichiometry: 0.0

F
Participant: Adenomatous polyposis coli protein

Participant: Adenomatous polyposis coli protein

Accession: EBI-6169745

Name: EBI-727707

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: Adenomatous polyposis coli protein

Participant: Adenomatous polyposis coli protein

Accession: EBI-6169745

Name: EBI-727707

Confidences:

Type
Value
No records found.

10
EBI-6169747
 logo
AMER1
FAM123B
Protein FAM123B

[+2]
APC membrane recruitment protein 1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
prey
Experimental role: prey
Accession: EBI-58

Name: prey

Description: prey

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0498
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally identified as being captured by a given bait.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: APC membrane recruitment protein 1

Participant: APC membrane recruitment protein 1

Accession: EBI-6169774

Name: EBI-6169747

P
Participant: APC membrane recruitment protein 1

Participant: APC membrane recruitment protein 1

Accession: EBI-6169774

Name: EBI-6169747

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: APC membrane recruitment protein 1

Participant: APC membrane recruitment protein 1

Accession: EBI-6169774

Name: EBI-6169747

Stoichiometry: 0.0

F
Participant: APC membrane recruitment protein 1

Participant: APC membrane recruitment protein 1

Accession: EBI-6169774

Name: EBI-6169747

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: APC membrane recruitment protein 1

Participant: APC membrane recruitment protein 1

Accession: EBI-6169774

Name: EBI-6169747

Confidences:

Type
Value
No records found.