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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 21729782

Journal: Cell (0092-8674)

Year of Publication: 2011

Title: Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors.

Author List: Takahashi H., Parmely T.J., Sato S., Tomomori-Sato C., Banks C.A., Kong S.E., Szutorisz H., Swanson S.K., Martin-Brown S., Washburn M.P., Florens L., Seidel C.W., Lin C., Smith E.R., Shilatifard A., Conaway R.C., Conaway J.W.

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
Apoptosis - Interactions involving proteins with a function related to apoptosis

Experiment (12 interactions)

Accession: EBI-4321305

Name: takahashi-2011-1

Host organism: Homo sapiens epitheloid cervix carcinoma cells

Organism: Homo sapiens epitheloid cervix carcinoma cells

Accession: EBI-307614

Name: human-hela

Description: Homo sapiens epitheloid cervix carcinoma cells

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human
-

Interaction Detection Method: anti tag coip

Interaction detection method: anti tag coip
Accession: EBI-90

Name: anti tag coip

Description: anti tag coimmunoprecipitation

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0007
-
identity
pubmed
7708014
-
primary-reference


Annotations:
Topic
Text
definition
A specific antibody for the molecule of interest is not available, therefore the bait protein is expressed as a hybrid protein fused to a tag peptide/protein for which efficient and specific antibodies or a specific ligand are available.


Participant Identification Method: mudpit

Participant identification method: mudpit
Accession: EBI-933988

Name: mudpit

Description: multidimensional protein identification technology

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0658
-
identity
pubmed
11231557
-
primary-reference


Annotations:
Topic
Text
definition
MudPIT is a method for rapid and large-scale protein identification by multidimensional liquid chromatography associated with tandem mass spectrometry. The chromatography step consists of strong cation exchange material back-to-back with reversed phase material inside fused silica capillaries. The peptides bound to the cation-exchange resin are freed by the gradually increasing salt concentration of the buffer and are subsequently retained by the reversed phase resin. Increasing buffers hydrophobicity progressively elute peptides from the reversed phase packing directly into the mass spectrometer. Typically this mass spectrometer will be a tandem electrospray, so peptides undergo ionization in the liquid phase, are separated in a primary mass spectrometer, analysed in the second mass spectrometer and identified.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
jlc@stowers.org
imex curation
Details of mediator protein constructs taken from PMID: 15175163
Only protein-protein interactions
-

Interaction

Accession: EBI-4321490

Name: med26-ccnc-1

Description: -

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0914
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
Fig. 1A, TABLE S1.

Participants (61)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
pp1234pp
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
pp1234pp
1
EBI-394392
 logo
ARC70
MED26
Mediator complex subunit 26

[+4]
Mediator of RNA polymerase II transcription subunit 26
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Mediator of RNA polymerase II transcription subunit 26

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-4321554

Name: EBI-394392

P
Participant: Mediator of RNA polymerase II transcription subunit 26

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-4321554

Name: EBI-394392

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Mediator of RNA polymerase II transcription subunit 26

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-4321554

Name: EBI-394392

Stoichiometry: 0.0

F
Participant: Mediator of RNA polymerase II transcription subunit 26

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-4321554

Name: EBI-394392

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
n-terminal
  • n-n
  • A
    Feature: EBI-4321555

    Feature: n-terminal

    Accession: EBI-4321555

    Name: n-terminal


    C
    Participant: Mediator of RNA polymerase II transcription subunit 26

    Participant: Mediator of RNA polymerase II transcription subunit 26

    Accession: EBI-4321554

    Name: EBI-394392

    Confidences:

    Type
    Value
    No records found.

    2
    EBI-394489
     logo
    TRAP170
    MED14
    ARC150

    [+12]
    Mediator of RNA polymerase II transcription subunit 14
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 14

    Participant: Mediator of RNA polymerase II transcription subunit 14

    Accession: EBI-4321492

    Name: EBI-394489

    P
    Participant: Mediator of RNA polymerase II transcription subunit 14

    Participant: Mediator of RNA polymerase II transcription subunit 14

    Accession: EBI-4321492

    Name: EBI-394489

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 14

    Participant: Mediator of RNA polymerase II transcription subunit 14

    Accession: EBI-4321492

    Name: EBI-394489

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 14

    Participant: Mediator of RNA polymerase II transcription subunit 14

    Accession: EBI-4321492

    Name: EBI-394489

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 14

    Participant: Mediator of RNA polymerase II transcription subunit 14

    Accession: EBI-4321492

    Name: EBI-394489

    Confidences:

    Type
    Value
    No records found.

    3
    EBI-311161
     logo
    MED23
    ARC130
    DRIP130

    [+9]
    Mediator of RNA polymerase II transcription subunit 23
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 23

    Participant: Mediator of RNA polymerase II transcription subunit 23

    Accession: EBI-4321493

    Name: EBI-311161

    P
    Participant: Mediator of RNA polymerase II transcription subunit 23

    Participant: Mediator of RNA polymerase II transcription subunit 23

    Accession: EBI-4321493

    Name: EBI-311161

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 23

    Participant: Mediator of RNA polymerase II transcription subunit 23

    Accession: EBI-4321493

    Name: EBI-311161

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 23

    Participant: Mediator of RNA polymerase II transcription subunit 23

    Accession: EBI-4321493

    Name: EBI-311161

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 23

    Participant: Mediator of RNA polymerase II transcription subunit 23

    Accession: EBI-4321493

    Name: EBI-311161

    Confidences:

    Type
    Value
    No records found.

    4
    EBI-394562
     logo
    TRAP80
    MED17
    ARC77

    [+9]
    Mediator of RNA polymerase II transcription subunit 17
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 17

    Participant: Mediator of RNA polymerase II transcription subunit 17

    Accession: EBI-4321494

    Name: EBI-394562

    P
    Participant: Mediator of RNA polymerase II transcription subunit 17

    Participant: Mediator of RNA polymerase II transcription subunit 17

    Accession: EBI-4321494

    Name: EBI-394562

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 17

    Participant: Mediator of RNA polymerase II transcription subunit 17

    Accession: EBI-4321494

    Name: EBI-394562

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 17

    Participant: Mediator of RNA polymerase II transcription subunit 17

    Accession: EBI-4321494

    Name: EBI-394562

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 17

    Participant: Mediator of RNA polymerase II transcription subunit 17

    Accession: EBI-4321494

    Name: EBI-394562

    Confidences:

    Type
    Value
    No records found.

    5
    EBI-395180
     logo
    POLRF
    POLR2F
    DNA-directed RNA polymerase II subunit F

    [+4]
    DNA-directed RNA polymerases I, II, and III subunit RPABC2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Accession: EBI-4321495

    Name: EBI-395180

    P
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Accession: EBI-4321495

    Name: EBI-395180

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Accession: EBI-4321495

    Name: EBI-395180

    Stoichiometry: 0.0

    F
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Accession: EBI-4321495

    Name: EBI-395180

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC2

    Accession: EBI-4321495

    Name: EBI-395180

    Confidences:

    Type
    Value
    No records found.

    6
    EBI-394558
     logo
    MED25
    ACID1
    ARC92

    [+6]
    Mediator of RNA polymerase II transcription subunit 25
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 25

    Participant: Mediator of RNA polymerase II transcription subunit 25

    Accession: EBI-4321496

    Name: EBI-394558

    P
    Participant: Mediator of RNA polymerase II transcription subunit 25

    Participant: Mediator of RNA polymerase II transcription subunit 25

    Accession: EBI-4321496

    Name: EBI-394558

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 25

    Participant: Mediator of RNA polymerase II transcription subunit 25

    Accession: EBI-4321496

    Name: EBI-394558

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 25

    Participant: Mediator of RNA polymerase II transcription subunit 25

    Accession: EBI-4321496

    Name: EBI-394558

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 25

    Participant: Mediator of RNA polymerase II transcription subunit 25

    Accession: EBI-4321496

    Name: EBI-394558

    Confidences:

    Type
    Value
    No records found.

    7
    EBI-394737
     logo
    POLR2D
    DNA-directed RNA polymerase II subunit D
    RNA polymerase II 16 kDa subunit
    DNA-directed RNA polymerase II subunit RPB4
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DNA-directed RNA polymerase II subunit RPB4

    Participant: DNA-directed RNA polymerase II subunit RPB4

    Accession: EBI-4321497

    Name: EBI-394737

    P
    Participant: DNA-directed RNA polymerase II subunit RPB4

    Participant: DNA-directed RNA polymerase II subunit RPB4

    Accession: EBI-4321497

    Name: EBI-394737

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DNA-directed RNA polymerase II subunit RPB4

    Participant: DNA-directed RNA polymerase II subunit RPB4

    Accession: EBI-4321497

    Name: EBI-394737

    Stoichiometry: 0.0

    F
    Participant: DNA-directed RNA polymerase II subunit RPB4

    Participant: DNA-directed RNA polymerase II subunit RPB4

    Accession: EBI-4321497

    Name: EBI-394737

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DNA-directed RNA polymerase II subunit RPB4

    Participant: DNA-directed RNA polymerase II subunit RPB4

    Accession: EBI-4321497

    Name: EBI-394737

    Confidences:

    Type
    Value
    No records found.

    8
    EBI-2620048
    Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Accession: EBI-4321498

    Name: EBI-2620048

    P
    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Accession: EBI-4321498

    Name: EBI-2620048

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Accession: EBI-4321498

    Name: EBI-2620048

    Stoichiometry: 0.0

    F
    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Accession: EBI-4321498

    Name: EBI-2620048

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Participant: Fusion of Human MLL (N -terminus) and Human AFF4 (518-1163) -C terminal region.

    Accession: EBI-4321498

    Name: EBI-2620048

    Confidences:

    Type
    Value
    No records found.

    9
    EBI-4321341
     logo
    MED8
    Activator-recruited cofactor 32 kDa component
    Mediator complex subunit 8
    Mediator of RNA polymerase II transcription subunit 8
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 8

    Participant: Mediator of RNA polymerase II transcription subunit 8

    Accession: EBI-4321499

    Name: EBI-4321341

    P
    Participant: Mediator of RNA polymerase II transcription subunit 8

    Participant: Mediator of RNA polymerase II transcription subunit 8

    Accession: EBI-4321499

    Name: EBI-4321341

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 8

    Participant: Mediator of RNA polymerase II transcription subunit 8

    Accession: EBI-4321499

    Name: EBI-4321341

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 8

    Participant: Mediator of RNA polymerase II transcription subunit 8

    Accession: EBI-4321499

    Name: EBI-4321341

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 8

    Participant: Mediator of RNA polymerase II transcription subunit 8

    Accession: EBI-4321499

    Name: EBI-4321341

    Confidences:

    Type
    Value
    No records found.

    10
    EBI-394354
     logo
    MED10
    L6
    TRG17

    [+4]
    Mediator of RNA polymerase II transcription subunit 10
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 10

    Participant: Mediator of RNA polymerase II transcription subunit 10

    Accession: EBI-4321500

    Name: EBI-394354

    P
    Participant: Mediator of RNA polymerase II transcription subunit 10

    Participant: Mediator of RNA polymerase II transcription subunit 10

    Accession: EBI-4321500

    Name: EBI-394354

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 10

    Participant: Mediator of RNA polymerase II transcription subunit 10

    Accession: EBI-4321500

    Name: EBI-394354

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 10

    Participant: Mediator of RNA polymerase II transcription subunit 10

    Accession: EBI-4321500

    Name: EBI-394354

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 10

    Participant: Mediator of RNA polymerase II transcription subunit 10

    Accession: EBI-4321500

    Name: EBI-394354

    Confidences:

    Type
    Value
    No records found.

    11
    EBI-394678
     logo
    SRB7
    MED21
    Mediator complex subunit 21

    [+2]
    Mediator of RNA polymerase II transcription subunit 21
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 21

    Participant: Mediator of RNA polymerase II transcription subunit 21

    Accession: EBI-4321501

    Name: EBI-394678

    P
    Participant: Mediator of RNA polymerase II transcription subunit 21

    Participant: Mediator of RNA polymerase II transcription subunit 21

    Accession: EBI-4321501

    Name: EBI-394678

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 21

    Participant: Mediator of RNA polymerase II transcription subunit 21

    Accession: EBI-4321501

    Name: EBI-394678

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 21

    Participant: Mediator of RNA polymerase II transcription subunit 21

    Accession: EBI-4321501

    Name: EBI-394678

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 21

    Participant: Mediator of RNA polymerase II transcription subunit 21

    Accession: EBI-4321501

    Name: EBI-394678

    Confidences:

    Type
    Value
    No records found.

    12
    EBI-359505
     logo
    POLR2H
    DNA-directed RNA polymerase II subunit H
    DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide

    [+2]
    DNA-directed RNA polymerases I, II, and III subunit RPABC3
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Accession: EBI-4321502

    Name: EBI-359505

    P
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Accession: EBI-4321502

    Name: EBI-359505

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Accession: EBI-4321502

    Name: EBI-359505

    Stoichiometry: 0.0

    F
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Accession: EBI-4321502

    Name: EBI-359505

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Participant: DNA-directed RNA polymerases I, II, and III subunit RPABC3

    Accession: EBI-4321502

    Name: EBI-359505

    Confidences:

    Type
    Value
    No records found.

    13
    EBI-394430
     logo
    MED19
    LCMR1
    Lung cancer metastasis-related protein 1

    [+1]
    Mediator of RNA polymerase II transcription subunit 19
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 19

    Participant: Mediator of RNA polymerase II transcription subunit 19

    Accession: EBI-4321503

    Name: EBI-394430

    P
    Participant: Mediator of RNA polymerase II transcription subunit 19

    Participant: Mediator of RNA polymerase II transcription subunit 19

    Accession: EBI-4321503

    Name: EBI-394430

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 19

    Participant: Mediator of RNA polymerase II transcription subunit 19

    Accession: EBI-4321503

    Name: EBI-394430

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 19

    Participant: Mediator of RNA polymerase II transcription subunit 19

    Accession: EBI-4321503

    Name: EBI-394430

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 19

    Participant: Mediator of RNA polymerase II transcription subunit 19

    Accession: EBI-4321503

    Name: EBI-394430

    Confidences:

    Type
    Value
    No records found.

    14
    EBI-394377
     logo
    CDK8
    Cell division protein kinase 8
    Mediator of RNA polymerase II transcription subunit CDK8

    [+2]
    Cyclin-dependent kinase 8
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Cyclin-dependent kinase 8

    Participant: Cyclin-dependent kinase 8

    Accession: EBI-4321504

    Name: EBI-394377

    P
    Participant: Cyclin-dependent kinase 8

    Participant: Cyclin-dependent kinase 8

    Accession: EBI-4321504

    Name: EBI-394377

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Cyclin-dependent kinase 8

    Participant: Cyclin-dependent kinase 8

    Accession: EBI-4321504

    Name: EBI-394377

    Stoichiometry: 0.0

    F
    Participant: Cyclin-dependent kinase 8

    Participant: Cyclin-dependent kinase 8

    Accession: EBI-4321504

    Name: EBI-394377

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Cyclin-dependent kinase 8

    Participant: Cyclin-dependent kinase 8

    Accession: EBI-4321504

    Name: EBI-394377

    Confidences:

    Type
    Value
    No records found.

    15
    EBI-514199
     logo
    Mediator complex subunit 28
    Tumor angiogenesis marker EG-1
    Endothelial-derived protein 1

    [+4]
    Mediator of RNA polymerase II transcription subunit 28
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 28

    Participant: Mediator of RNA polymerase II transcription subunit 28

    Accession: EBI-4321505

    Name: EBI-514199

    P
    Participant: Mediator of RNA polymerase II transcription subunit 28

    Participant: Mediator of RNA polymerase II transcription subunit 28

    Accession: EBI-4321505

    Name: EBI-514199

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 28

    Participant: Mediator of RNA polymerase II transcription subunit 28

    Accession: EBI-4321505

    Name: EBI-514199

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 28

    Participant: Mediator of RNA polymerase II transcription subunit 28

    Accession: EBI-4321505

    Name: EBI-514199

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 28

    Participant: Mediator of RNA polymerase II transcription subunit 28

    Accession: EBI-4321505

    Name: EBI-514199

    Confidences:

    Type
    Value
    No records found.

    16
    EBI-394704
     logo
    Mediator complex subunit 11
    MED11
    HSPC296
    Mediator of RNA polymerase II transcription subunit 11
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 11

    Participant: Mediator of RNA polymerase II transcription subunit 11

    Accession: EBI-4321506

    Name: EBI-394704

    P
    Participant: Mediator of RNA polymerase II transcription subunit 11

    Participant: Mediator of RNA polymerase II transcription subunit 11

    Accession: EBI-4321506

    Name: EBI-394704

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 11

    Participant: Mediator of RNA polymerase II transcription subunit 11

    Accession: EBI-4321506

    Name: EBI-394704

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 11

    Participant: Mediator of RNA polymerase II transcription subunit 11

    Accession: EBI-4321506

    Name: EBI-394704

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 11

    Participant: Mediator of RNA polymerase II transcription subunit 11

    Accession: EBI-4321506

    Name: EBI-394704

    Confidences:

    Type
    Value
    No records found.

    17
    EBI-394440
     logo
    TRAP240
    MED13
    ARC250

    [+7]
    Mediator of RNA polymerase II transcription subunit 13
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 13

    Participant: Mediator of RNA polymerase II transcription subunit 13

    Accession: EBI-4321507

    Name: EBI-394440

    P
    Participant: Mediator of RNA polymerase II transcription subunit 13

    Participant: Mediator of RNA polymerase II transcription subunit 13

    Accession: EBI-4321507

    Name: EBI-394440

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 13

    Participant: Mediator of RNA polymerase II transcription subunit 13

    Accession: EBI-4321507

    Name: EBI-394440

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 13

    Participant: Mediator of RNA polymerase II transcription subunit 13

    Accession: EBI-4321507

    Name: EBI-394440

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 13

    Participant: Mediator of RNA polymerase II transcription subunit 13

    Accession: EBI-4321507

    Name: EBI-394440

    Confidences:

    Type
    Value
    No records found.

    18
    EBI-394707
     logo
    CGI-125
    SOH1
    MED31

    [+2]
    Mediator of RNA polymerase II transcription subunit 31
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Mediator of RNA polymerase II transcription subunit 31

    Participant: Mediator of RNA polymerase II transcription subunit 31

    Accession: EBI-4321508

    Name: EBI-394707

    P
    Participant: Mediator of RNA polymerase II transcription subunit 31

    Participant: Mediator of RNA polymerase II transcription subunit 31

    Accession: EBI-4321508

    Name: EBI-394707

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Mediator of RNA polymerase II transcription subunit 31

    Participant: Mediator of RNA polymerase II transcription subunit 31

    Accession: EBI-4321508

    Name: EBI-394707

    Stoichiometry: 0.0

    F
    Participant: Mediator of RNA polymerase II transcription subunit 31

    Participant: Mediator of RNA polymerase II transcription subunit 31

    Accession: EBI-4321508

    Name: EBI-394707

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Mediator of RNA polymerase II transcription subunit 31

    Participant: Mediator of RNA polymerase II transcription subunit 31

    Accession: EBI-4321508

    Name: EBI-394707

    Confidences:

    Type
    Value
    No records found.

    19
    EBI-394712
     logo
    POLR2B
    DNA-directed RNA polymerase II subunit B
    RNA polymerase II subunit B2

    [+2]
    DNA-directed RNA polymerase II subunit RPB2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DNA-directed RNA polymerase II subunit RPB2

    Participant: DNA-directed RNA polymerase II subunit RPB2

    Accession: EBI-4321509

    Name: EBI-394712

    P
    Participant: DNA-directed RNA polymerase II subunit RPB2

    Participant: DNA-directed RNA polymerase II subunit RPB2

    Accession: EBI-4321509

    Name: EBI-394712

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DNA-directed RNA polymerase II subunit RPB2

    Participant: DNA-directed RNA polymerase II subunit RPB2

    Accession: EBI-4321509

    Name: EBI-394712

    Stoichiometry: 0.0

    F
    Participant: DNA-directed RNA polymerase II subunit RPB2

    Participant: DNA-directed RNA polymerase II subunit RPB2

    Accession: EBI-4321509

    Name: EBI-394712

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DNA-directed RNA polymerase II subunit RPB2

    Participant: DNA-directed RNA polymerase II subunit RPB2

    Accession: EBI-4321509

    Name: EBI-394712

    Confidences:

    Type
    Value
    No records found.

    20
    EBI-347928
     logo
    POLR2G
    DNA-directed RNA polymerase II subunit G
    RPB7

    [+1]
    DNA-directed RNA polymerase II subunit RPB7
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DNA-directed RNA polymerase II subunit RPB7

    Participant: DNA-directed RNA polymerase II subunit RPB7

    Accession: EBI-4321510

    Name: EBI-347928

    P
    Participant: DNA-directed RNA polymerase II subunit RPB7

    Participant: DNA-directed RNA polymerase II subunit RPB7

    Accession: EBI-4321510

    Name: EBI-347928

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DNA-directed RNA polymerase II subunit RPB7

    Participant: DNA-directed RNA polymerase II subunit RPB7

    Accession: EBI-4321510

    Name: EBI-347928

    Stoichiometry: 0.0

    F
    Participant: DNA-directed RNA polymerase II subunit RPB7

    Participant: DNA-directed RNA polymerase II subunit RPB7

    Accession: EBI-4321510

    Name: EBI-347928

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DNA-directed RNA polymerase II subunit RPB7

    Participant: DNA-directed RNA polymerase II subunit RPB7

    Accession: EBI-4321510

    Name: EBI-347928

    Confidences:

    Type
    Value
    No records found.


    Graphical Representation of Experimental Features