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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.

What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

Try the query: imatinib
This is a drug for which we have curated a number of interactions.
Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
Try the query: species:yeast AND type:"direct interaction"
This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

Gene Ontology
InterPro
PSI-MI
ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.

Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.

PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

Interacting with the widget

Hover over a feature to see more information in a tooltip.

To display a single interacting region click on it and click again to display all interacting regions.

Displaying all interacting regions	Displaying one interacting region

What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 14576168

Journal: J. Biol. Chem. (0021-9258)

Year of Publication: 2003

Title: A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.

Author List: Sato S., Tomomori-Sato C., Banks CA., Parmely TJ., Sorokina I., Brower CS., Conaway RC., Conaway JW.

Links

Show all interactions

Cross References:

Database	Identifier	Secondary identifier	Qualifier
mint	MINT-5216777	-	primary-reference
pubmed	14576168	-	primary-reference

Experiment (2 interactions)

Accession: EBI-399561

Name: sato-2003a-2

Host organism: Homo sapiens epitheloid cervix carcinoma cells

Organism: Homo sapiens epitheloid cervix carcinoma cells

Accession: EBI-307614

Name: human-hela

Description: Homo sapiens epitheloid cervix carcinoma cells

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity
cabri	ACC 57	-	identity

Interaction Detection Method: anti tag coip

Interaction detection method: anti tag coip

Accession: EBI-90

Name: anti tag coip

Description: anti tag coimmunoprecipitation

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0007	-	identity
pubmed	7708014	-	primary-reference

Annotations:

Topic	Text
definition	A specific antibody for the molecule of interest is not available, therefore the bait protein is expressed as a hybrid protein fused to a tag peptide/protein for which efficient and specific antibodies or a specific ligand are available.

Participant Identification Method: fingerprinting

Participant identification method: fingerprinting

Accession: EBI-70

Name: fingerprinting

Description: peptide massfingerprinting

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0082	-	identity
pubmed	10967324	-	primary-reference
pubmed	11752590	-	primary-reference
pubmed	11805826	-	primary-reference

Annotations:

Topic	Text
definition	This approach leads to protein identification by matching peptide masses, as measured by mass spectrometry, to the ones calculated from in silico fragmentation of a protein sequence database. A peptide mixture from a tryptic digest is analysed by MALDI-MS (Matrix-assisted laser desorption ionization mass spectrometry). The list of peptide masses obtained by MALDI MS is automatically compared to the calculated masses of the predicted peptide fragments for each entry in the database. High mass accuracy is very important in order to obtain a statistically significant and unambiguous match This method is best applied to completely sequenced genomes and well characterised proteomes. However, depending on the data quality, proteins that are highly homologous to already characterised proteins (greater than 80 to 90% sequence identity) can also be identified. The retrieved sequence are evaluated by mass accuracy of the peptides, matching of additional peptide masses in the MALDI spectrum after accounting for common modifications such as oxidation, acrylamidation of cysteine and missed cleavages and the use of secondary information (apparent isoelectric point and molecular weight). If any ambiguity about the identification by MALDI-MS still exists, the results must verified by an other identification method. Peptide mass fingerprint is generally carried out with a MALDI-TOF (Matrix-assisted laser desorption ionization time-of-flight ) instrument but can also be achieved ESI-TOF (Electrospray Ionisation time-of-flight) or LC-MS (Liquid Chromatography-Mass Spectrometry) mass spectrometer.

Topic

Text

definition

This approach leads to protein identification by matching peptide masses, as measured by mass spectrometry, to the ones calculated from in silico fragmentation of a protein sequence database. A peptide mixture from a tryptic digest is analysed by MALDI-MS (Matrix-assisted laser desorption ionization mass spectrometry). The list of peptide masses obtained by MALDI MS is automatically compared to the calculated masses of the predicted peptide fragments for each entry in the database. High mass accuracy is very important in order to obtain a statistically significant and unambiguous match This method is best applied to completely sequenced genomes and well characterised proteomes. However, depending on the data quality, proteins that are highly homologous to already characterised proteins (greater than 80 to 90% sequence identity) can also be identified. The retrieved sequence are evaluated by mass accuracy of the peptides, matching of additional peptide masses in the MALDI spectrum after accounting for common modifications such as oxidation, acrylamidation of cysteine and missed cleavages and the use of secondary information (apparent isoelectric point and molecular weight). If any ambiguity about the identification by MALDI-MS still exists, the results must verified by an other identification method. Peptide mass fingerprint is generally carried out with a MALDI-TOF (Matrix-assisted laser desorption ionization time-of-flight ) instrument but can also be achieved ESI-TOF (Electrospray Ionisation time-of-flight) or LC-MS (Liquid Chromatography-Mass Spectrometry) mass spectrometer.

Cross References:

Database	Identifier	Secondary identifier	Qualifier
pubmed	14576168	-	primary-reference

Interaction

Accession: EBI-399620

Name: ixl-crsp6-5

Description: Interaction detected by Anti FLAG affinity chromatography.

Type: association

Interaction type: association

Accession: EBI-1813191

Name: association

Description: association

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0914	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.

Links

Find similar interactions

Annotations:

Topic	Text
comment	FLAG-LCMR1 used in experiment.

Participants (25)

Legend:

Annotation and Cross Reference

Experimental Parameter

Stoichiometry

Experimental Feature

Participant Confidence

pp12pp

Name

Links

Primary Identifier

Aliases

Description

Species

Expression system

Experimental role

Biological role

Interactor type

More...

pp12pp

EBI-394430

A0JLT2

MED19
LCMR1
Lung cancer metastasis-related protein 1

[+1]

Mediator of RNA polymerase II transcription subunit 19

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

bait

Experimental role: bait

Accession: EBI-49

Name: bait

Description: bait

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0496	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally treated to capture its interacting partners.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399647

Name: EBI-394430

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399647

Name: EBI-394430

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399647

Name: EBI-394430

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399647

Name: EBI-394430

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
region	flag tag		?-?	A Feature: EBI-611099 Feature: region Accession: EBI-611099 Name: region

Feature Range Legend (x is a position in the interactor sequence):

n: n-terminal range
c: c-terminal range
?: undetermined position
x..x: range from x to x
>x: greater than x
<x: less than x
x: certain position

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399647

Name: EBI-394430

Confidences:

Type	Value
No records found.

EBI-394562

Q9NVC6
DIP-31451N

TRAP80
MED17
ARC77

[+9]

Mediator of RNA polymerase II transcription subunit 17

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 17

Accession: EBI-399621

Name: EBI-394562

Participant: Mediator of RNA polymerase II transcription subunit 17

Accession: EBI-399621

Name: EBI-394562

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 17

Accession: EBI-399621

Name: EBI-394562

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 17

Accession: EBI-399621

Name: EBI-394562

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 17

Accession: EBI-399621

Name: EBI-394562

Confidences:

Type	Value
No records found.

EBI-394640

Q9BUE0

MED18
Mediator complex subunit 18
p28b

Mediator of RNA polymerase II transcription subunit 18

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 18

Accession: EBI-399622

Name: EBI-394640

Participant: Mediator of RNA polymerase II transcription subunit 18

Accession: EBI-399622

Name: EBI-394640

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 18

Accession: EBI-399622

Name: EBI-394640

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 18

Accession: EBI-399622

Name: EBI-394640

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 18

Accession: EBI-399622

Name: EBI-394640

Confidences:

Type	Value
No records found.

EBI-394707

Q9Y3C7

CGI-125
SOH1
MED31

[+2]

Mediator of RNA polymerase II transcription subunit 31

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 31

Accession: EBI-399623

Name: EBI-394707

Participant: Mediator of RNA polymerase II transcription subunit 31

Accession: EBI-399623

Name: EBI-394707

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 31

Accession: EBI-399623

Name: EBI-394707

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 31

Accession: EBI-399623

Name: EBI-394707

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 31

Accession: EBI-399623

Name: EBI-394707

Confidences:

Type	Value
No records found.

EBI-394624

O75586

ARC33
MED6
Mediator complex subunit 6

[+2]

Mediator of RNA polymerase II transcription subunit 6

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 6

Accession: EBI-399624

Name: EBI-394624

Participant: Mediator of RNA polymerase II transcription subunit 6

Accession: EBI-399624

Name: EBI-394624

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 6

Accession: EBI-399624

Name: EBI-394624

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 6

Accession: EBI-399624

Name: EBI-394624

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 6

Accession: EBI-399624

Name: EBI-394624

Confidences:

Type	Value
No records found.

EBI-394405

Q96G25

MED8
Mediator complex subunit 8
Activator-recruited cofactor 32 kDa component

Mediator of RNA polymerase II transcription subunit 8

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 8

Accession: EBI-399626

Name: EBI-394405

Participant: Mediator of RNA polymerase II transcription subunit 8

Accession: EBI-399626

Name: EBI-394405

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 8

Accession: EBI-399626

Name: EBI-394405

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 8

Accession: EBI-399626

Name: EBI-394405

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 8

Accession: EBI-399626

Name: EBI-394405

Confidences:

Type	Value
No records found.

EBI-394644

Q9H944

TRFP
MED20
Mediator complex subunit 20

[+1]

Mediator of RNA polymerase II transcription subunit 20

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 20

Accession: EBI-399627

Name: EBI-394644

Participant: Mediator of RNA polymerase II transcription subunit 20

Accession: EBI-399627

Name: EBI-394644

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 20

Accession: EBI-399627

Name: EBI-394644

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 20

Accession: EBI-399627

Name: EBI-394644

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 20

Accession: EBI-399627

Name: EBI-394644

Confidences:

Type	Value
No records found.

EBI-394357

Q93074

TRAP230
MED12
ARC240

[+10]

Mediator of RNA polymerase II transcription subunit 12

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 12

Accession: EBI-399629

Name: EBI-394357

Participant: Mediator of RNA polymerase II transcription subunit 12

Accession: EBI-399629

Name: EBI-394357

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 12

Accession: EBI-399629

Name: EBI-394357

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 12

Accession: EBI-399629

Name: EBI-394357

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 12

Accession: EBI-399629

Name: EBI-394357

Confidences:

Type	Value
No records found.

EBI-394459

Q15648
DIP-24212N

TRIP2
MED1
ARC205

[+16]

Mediator of RNA polymerase II transcription subunit 1

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 1

Accession: EBI-399630

Name: EBI-394459

Participant: Mediator of RNA polymerase II transcription subunit 1

Accession: EBI-399630

Name: EBI-394459

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 1

Accession: EBI-399630

Name: EBI-394459

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 1

Accession: EBI-399630

Name: EBI-394459

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 1

Accession: EBI-399630

Name: EBI-394459

Confidences:

Type	Value
No records found.

EBI-394489

O60244

TRAP170
MED14
ARC150

[+12]

Mediator of RNA polymerase II transcription subunit 14

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 14

Accession: EBI-399631

Name: EBI-394489

Participant: Mediator of RNA polymerase II transcription subunit 14

Accession: EBI-399631

Name: EBI-394489

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 14

Accession: EBI-399631

Name: EBI-394489

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 14

Accession: EBI-399631

Name: EBI-394489

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 14

Accession: EBI-399631

Name: EBI-394489

Confidences:

Type	Value
No records found.

EBI-311176

Q9ULK4-1

MED23
ARC130
CRSP3

[+9]

Mediator of RNA polymerase II transcription subunit 23

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 23

Accession: EBI-399632

Name: EBI-311176

Participant: Mediator of RNA polymerase II transcription subunit 23

Accession: EBI-399632

Name: EBI-311176

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 23

Accession: EBI-399632

Name: EBI-311176

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 23

Accession: EBI-399632

Name: EBI-311176

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 23

Accession: EBI-399632

Name: EBI-311176

Confidences:

Type	Value
No records found.

EBI-394523

O75448

TRAP100
MED24
DRIP100

[+10]

Mediator of RNA polymerase II transcription subunit 24

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 24

Accession: EBI-399633

Name: EBI-394523

Participant: Mediator of RNA polymerase II transcription subunit 24

Accession: EBI-399633

Name: EBI-394523

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 24

Accession: EBI-399633

Name: EBI-394523

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 24

Accession: EBI-399633

Name: EBI-394523

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 24

Accession: EBI-399633

Name: EBI-394523

Confidences:

Type	Value
No records found.

EBI-394541

Q9Y2X0

MED16
Mediator complex subunit 16
Thyroid hormone receptor-associated protein complex 95 kDa component

[+4]

Mediator of RNA polymerase II transcription subunit 16

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 16

Accession: EBI-399634

Name: EBI-394541

Participant: Mediator of RNA polymerase II transcription subunit 16

Accession: EBI-399634

Name: EBI-394541

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 16

Accession: EBI-399634

Name: EBI-394541

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 16

Accession: EBI-399634

Name: EBI-394541

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 16

Accession: EBI-399634

Name: EBI-394541

Confidences:

Type	Value
No records found.

EBI-394392

O95402

ARC70
MED26
Mediator complex subunit 26

[+4]

Mediator of RNA polymerase II transcription subunit 26

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-399636

Name: EBI-394392

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-399636

Name: EBI-394392

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-399636

Name: EBI-394392

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-399636

Name: EBI-394392

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 26

Accession: EBI-399636

Name: EBI-394392

Confidences:

Type	Value
No records found.

EBI-394603

Q6P2C8

MED27
Mediator complex subunit 27
Cofactor required for Sp1 transcriptional activation subunit 8

[+4]

Mediator of RNA polymerase II transcription subunit 27

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 27

Accession: EBI-399637

Name: EBI-394603

Participant: Mediator of RNA polymerase II transcription subunit 27

Accession: EBI-399637

Name: EBI-394603

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 27

Accession: EBI-399637

Name: EBI-394603

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 27

Accession: EBI-399637

Name: EBI-394603

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 27

Accession: EBI-399637

Name: EBI-394603

Confidences:

Type	Value
No records found.

EBI-394607

Q9NPJ6

HSPC126
DRIP36
MED4

[+6]

Mediator of RNA polymerase II transcription subunit 4

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 4

Accession: EBI-399638

Name: EBI-394607

Participant: Mediator of RNA polymerase II transcription subunit 4

Accession: EBI-399638

Name: EBI-394607

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 4

Accession: EBI-399638

Name: EBI-394607

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 4

Accession: EBI-399638

Name: EBI-394607

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 4

Accession: EBI-399638

Name: EBI-394607

Confidences:

Type	Value
No records found.

EBI-394430

A0JLT2

MED19
LCMR1
Lung cancer metastasis-related protein 1

[+1]

Mediator of RNA polymerase II transcription subunit 19

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399639

Name: EBI-394430

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399639

Name: EBI-394430

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399639

Name: EBI-394430

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399639

Name: EBI-394430

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 19

Accession: EBI-399639

Name: EBI-394430

Confidences:

Type	Value
No records found.

EBI-394440

Q9UHV7

TRAP240
MED13
ARC250

[+7]

Mediator of RNA polymerase II transcription subunit 13

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 13

Accession: EBI-399640

Name: EBI-394440

Participant: Mediator of RNA polymerase II transcription subunit 13

Accession: EBI-399640

Name: EBI-394440

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 13

Accession: EBI-399640

Name: EBI-394440

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 13

Accession: EBI-399640

Name: EBI-394440

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 13

Accession: EBI-399640

Name: EBI-394440

Confidences:

Type	Value
No records found.

EBI-394659

Q96HR3

TRAP25
MED30
Mediator complex subunit 30

[+4]

Mediator of RNA polymerase II transcription subunit 30

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 30

Accession: EBI-399641

Name: EBI-394659

Participant: Mediator of RNA polymerase II transcription subunit 30

Accession: EBI-399641

Name: EBI-394659

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 30

Accession: EBI-399641

Name: EBI-394659

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 30

Accession: EBI-399641

Name: EBI-394659

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 30

Accession: EBI-399641

Name: EBI-394659

Confidences:

Type	Value
No records found.

EBI-394656

Q9NX70

MED29
Mediator complex subunit 29
Intersex-like protein

[+1]

Mediator of RNA polymerase II transcription subunit 29

Homo sapiens

Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database	Identifier	Secondary identifier	Qualifier
uniprot taxonomy	9606	human	identity

Expressed In Details

Accession:

Name:

prey

Experimental role: prey

Accession: EBI-58

Name: prey

Description: prey

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0498	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Molecule experimentally identified as being captured by a given bait.

unspecified role

Biological role: unspecified role

Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:

Database	Identifier	Secondary identifier	Qualifier
psi-mi	MI:0499	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	Role not specified or not applicable to the data.

protein

Interactor type: protein

Accession: EBI-619654

Name: protein

Description: protein

Cross References:

Database	Identifier	Secondary identifier	Qualifier
so	SO:0000358	-	see-also
psi-mi	MI:0326	-	identity
pubmed	14755292	-	primary-reference

Annotations:

Topic	Text
definition	A linear polymer of amino acids joined by peptide bonds in a specific sequence.

Participant: Mediator of RNA polymerase II transcription subunit 29

Accession: EBI-399642

Name: EBI-394656

Participant: Mediator of RNA polymerase II transcription subunit 29

Accession: EBI-399642

Name: EBI-394656

Parameters:

Type	Value	Unit	Base	Exponent	Uncertainty
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 29

Accession: EBI-399642

Name: EBI-394656

Stoichiometry: 0.0

Participant: Mediator of RNA polymerase II transcription subunit 29

Accession: EBI-399642

Name: EBI-394656

Features:

Legend:

Annotation and Cross Reference

Feature Name	Feature Type	Detection Method	Range positions	More...
No records found.

Participant: Mediator of RNA polymerase II transcription subunit 29

Accession: EBI-399642

Name: EBI-394656

Confidences:

Type	Value
No records found.

Graphical Representation of Experimental Features

What is this image helpIcon

Scroll

Binary interactions

Description of what has changed

Configuring the view to your need"

Downloading the data into Standard formats"

Opening the interaction details"

Browsing (Browse Tab)

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Limiting the scope of the current dataset with the GO ontology

Limiting the scope of the current dataset with the ChEBI ontology

Bulk linking to third party resources by using involved proteins

Searching Interactions (Search Tab)

Using the Quick Search

Using the Ontology Search

Searching the Compound chemical structure

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Existing expansion algorithm

How is the number of interactions in other databases obtained?

What is the significance of the IMEx dataset?"

Representation of Experimental Features

Interacting with the widget

Dynamic molecular interaction data

Publication

Experiment (2 interactions)

Interaction

Participants (25)

Participant: Mediator of RNA polymerase II transcription subunit 19

Participant: Mediator of RNA polymerase II transcription subunit 19

Participant: Mediator of RNA polymerase II transcription subunit 19

Participant: Mediator of RNA polymerase II transcription subunit 19

Feature: region

Participant: Mediator of RNA polymerase II transcription subunit 19

Participant: Mediator of RNA polymerase II transcription subunit 17

Participant: Mediator of RNA polymerase II transcription subunit 17

Participant: Mediator of RNA polymerase II transcription subunit 17

Participant: Mediator of RNA polymerase II transcription subunit 17

Participant: Mediator of RNA polymerase II transcription subunit 17

Participant: Mediator of RNA polymerase II transcription subunit 18

Participant: Mediator of RNA polymerase II transcription subunit 18

Participant: Mediator of RNA polymerase II transcription subunit 18

Participant: Mediator of RNA polymerase II transcription subunit 18

Participant: Mediator of RNA polymerase II transcription subunit 18

Participant: Mediator of RNA polymerase II transcription subunit 31

Participant: Mediator of RNA polymerase II transcription subunit 31

Participant: Mediator of RNA polymerase II transcription subunit 31

Participant: Mediator of RNA polymerase II transcription subunit 31

Participant: Mediator of RNA polymerase II transcription subunit 31

Participant: Mediator of RNA polymerase II transcription subunit 6

Participant: Mediator of RNA polymerase II transcription subunit 6

Participant: Mediator of RNA polymerase II transcription subunit 6

Participant: Mediator of RNA polymerase II transcription subunit 6

Participant: Mediator of RNA polymerase II transcription subunit 6

Participant: Mediator of RNA polymerase II transcription subunit 8

Participant: Mediator of RNA polymerase II transcription subunit 8

Participant: Mediator of RNA polymerase II transcription subunit 8

Participant: Mediator of RNA polymerase II transcription subunit 8

Participant: Mediator of RNA polymerase II transcription subunit 8

Participant: Mediator of RNA polymerase II transcription subunit 20

Participant: Mediator of RNA polymerase II transcription subunit 20

Participant: Mediator of RNA polymerase II transcription subunit 20

Participant: Mediator of RNA polymerase II transcription subunit 20

Participant: Mediator of RNA polymerase II transcription subunit 20

Participant: Mediator of RNA polymerase II transcription subunit 12

Participant: Mediator of RNA polymerase II transcription subunit 12

Participant: Mediator of RNA polymerase II transcription subunit 12

Participant: Mediator of RNA polymerase II transcription subunit 12

Participant: Mediator of RNA polymerase II transcription subunit 12

Participant: Mediator of RNA polymerase II transcription subunit 1

Participant: Mediator of RNA polymerase II transcription subunit 1

Participant: Mediator of RNA polymerase II transcription subunit 1

Participant: Mediator of RNA polymerase II transcription subunit 1

Participant: Mediator of RNA polymerase II transcription subunit 1

Participant: Mediator of RNA polymerase II transcription subunit 14

Participant: Mediator of RNA polymerase II transcription subunit 14

Participant: Mediator of RNA polymerase II transcription subunit 14

Participant: Mediator of RNA polymerase II transcription subunit 14

Participant: Mediator of RNA polymerase II transcription subunit 14

Participant: Mediator of RNA polymerase II transcription subunit 23

Participant: Mediator of RNA polymerase II transcription subunit 23

Participant: Mediator of RNA polymerase II transcription subunit 23