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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 27474268

Journal: Molecular systems biology

Year of Publication: 2016

Title: Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.

Author List: Voisinne G., García-Blesa A., Chaoui K., Fiore F., Bergot E., Girard L., Malissen M., Burlet-Schiltz O., Gonzalez de Peredo A., Malissen B., Roncagalli R.

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Experiment (5 interactions)

Accession: EBI-12600181

Name: voisinne-2016-1

Host organism: Mouse CD4 positive T-cell

Organism: Mouse CD4 positive T-cell

Accession: EBI-8852357

Name: mouse-t-cell_cd4+

Description: Mouse CD4 positive T-cell

Cross References:

Database
Identifier
Secondary identifier
Qualifier
mouse

Interaction Detection Method: affinity chrom

Interaction detection method: affinity chrom
Accession: EBI-86

Name: affinity chrom

Description: affinity chromatography technology

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0004
-
identity
pubmed
7708014
-
primary-reference


Annotations:
Topic
Text
definition
This class of approaches is characterised by the use of affinity resins as tools to purify molecule of interest (baits) and their binding partners. The baits can be captured by a variety of high affinity ligands linked to a resin - for example, antibodies specific for the bait itself, antibodies for specific tags engineered to be expressed as part of the bait or other high affinity binders such as glutathione resins for GST fusion proteins, metal resins for histidine-tagged proteins.


Participant Identification Method: sequence tag

Participant identification method: sequence tag
Accession: EBI-81

Name: sequence tag

Description: sequence tag identification

Cross References:
Database
Identifier
Secondary identifier
Qualifier
pubmed
11805837
-
see-also
psi-mi
MI:0102
-
identity
pubmed
10967324
-
primary-reference
pubmed
11752590
-
primary-reference


Annotations:
Topic
Text
definition
This approach leads to protein identification by combining mass measurement and short amino acid sequence information obtained by tandem mass spectrometry. This information is then used to automatically find the best match in a sequence database. A mixture of peptides derived from a protease digestion is analysed by nanoelectrospray LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometer or nanoESI MS/MS) mass spectrometry. Electrospray mass spectrometry cannot be applied to dilute samples and is affected by high salt. As a consequence peptides, normally extracted from acrylamide gels by in situ proteolysis, are desalted and concentrated on a microcolumn followed by elution into a capillary used for nanoelectrospray tandem mass spectrometry. A first mass spectrum (Normal mass spectrum or Q1 mass spectrum) gives information about the masses of all the peptides. Peptides observed in the normal mass spectrum are isolated in turn and dissociated into fragments by collision with gas molecules within the mass spectrometer. Some of the fragments obtained from a peptide constitute a nested set, differing by one amino acid, and the mass difference between them allows assignment of a partial sequence. The masses of the fragments define the position of the partial sequence in the peptide. Together with the cleavage specificity of the protease used to cleave the protein, and mass information such sequence tag provides much higher search specificity to match the a database entry. The procedure is repeated with several peptides from the digest, resulting in multiple identifications of the same protein or identification of several proteins from the peptide mixture. Unknown proteins can easily be identified by using the high specificity of the peptide sequence tag for searches in most sequence databases including EST or genome databases.


Cross References:

Annotations:

Topic
Text
bernardm@ciml.univ-mrs.fr,roncagalli@ciml.univ-mrs.fr
imex curation
notify when curated
Cd4+ cells (purified from pooled lymph nodes and spleens) were were left unstimulated or stimulated for 30, 120, 300, or 600 s with anti‐CD3 and anti‐CD4 antibodies. They were then affinity purified on Strep‐Tactin Sepharose beads and eluted with biotin.
No entries have been made for the protein "PCB" as it cannot be uniquely identified. Only proteins given an approximate P(Detection) value of >0.3 have been entered here, as deduced from colour intensity in Figure 2C/D.

Interaction

Accession: EBI-12600767

Name: cbl-17

Description: -

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0914
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Fig 2D, Dataset Ev1, Sheet A.iv

Participants (61)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
pp1234pp
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
pp1234pp
1
EBI-640919
 logo
Signal transduction protein CBL
Proto-oncogene c-Cbl
Casitas B-lineage lymphoma proto-oncogene

[+2]
E3 ubiquitin-protein ligase CBL
Mus musculus
Organism Details

Accession: EBI-1329

Name: mouse

Description: Mus musculus

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
mouse

Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: E3 ubiquitin-protein ligase CBL

Participant: E3 ubiquitin-protein ligase CBL

Accession: EBI-12600769

Name: EBI-640919

P
Participant: E3 ubiquitin-protein ligase CBL

Participant: E3 ubiquitin-protein ligase CBL

Accession: EBI-12600769

Name: EBI-640919

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: E3 ubiquitin-protein ligase CBL

Participant: E3 ubiquitin-protein ligase CBL

Accession: EBI-12600769

Name: EBI-640919

Stoichiometry: 0.0

F
Participant: E3 ubiquitin-protein ligase CBL

Participant: E3 ubiquitin-protein ligase CBL

Accession: EBI-12600769

Name: EBI-640919

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
OST-modified_strep2_tag
  • c-c
  • A
    Feature: EBI-12600770

    Feature: OST-modified_strep2_tag

    Accession: EBI-12600770

    Name: OST-modified_strep2_tag


    C
    Participant: E3 ubiquitin-protein ligase CBL

    Participant: E3 ubiquitin-protein ligase CBL

    Accession: EBI-12600769

    Name: EBI-640919

    Confidences:

    Type
    Value
    No records found.

    2
    EBI-2642655
     logo
    Crkol
    Crkl
    Crk-like protein
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Crk-like protein

    Participant: Crk-like protein

    Accession: EBI-12601078

    Name: EBI-2642655

    P
    Participant: Crk-like protein

    Participant: Crk-like protein

    Accession: EBI-12601078

    Name: EBI-2642655

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Crk-like protein

    Participant: Crk-like protein

    Accession: EBI-12601078

    Name: EBI-2642655

    Stoichiometry: 0.0

    F
    Participant: Crk-like protein

    Participant: Crk-like protein

    Accession: EBI-12601078

    Name: EBI-2642655

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Crk-like protein

    Participant: Crk-like protein

    Accession: EBI-12601078

    Name: EBI-2642655

    Confidences:

    Type
    Value
    No records found.

    3
    EBI-12600397
     logo
    Ubash3a
    Suppressor of T-cell receptor signaling 2
    T-cell ubiquitin ligand 1

    [+1]
    Ubiquitin-associated and SH3 domain-containing protein A
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Accession: EBI-12601079

    Name: EBI-12600397

    P
    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Accession: EBI-12601079

    Name: EBI-12600397

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Accession: EBI-12601079

    Name: EBI-12600397

    Stoichiometry: 0.0

    F
    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Accession: EBI-12601079

    Name: EBI-12600397

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Participant: Ubiquitin-associated and SH3 domain-containing protein A

    Accession: EBI-12601079

    Name: EBI-12600397

    Confidences:

    Type
    Value
    No records found.

    4
    EBI-641764
     logo
    Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
    Pik3r1
    Phosphatidylinositol 3-kinase regulatory subunit alpha
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Accession: EBI-12601080

    Name: EBI-641764

    P
    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Accession: EBI-12601080

    Name: EBI-641764

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Accession: EBI-12601080

    Name: EBI-641764

    Stoichiometry: 0.0

    F
    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Accession: EBI-12601080

    Name: EBI-641764

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Participant: Phosphatidylinositol 3-kinase regulatory subunit alpha

    Accession: EBI-12601080

    Name: EBI-641764

    Confidences:

    Type
    Value
    No records found.

    5
    EBI-642709
     logo
    SH3-containing, expressed in tumorigenic astrocytes
    Regulator of ubiquitous kinase
    Sh3kbp1

    [+2]
    SH3 domain-containing kinase-binding protein 1
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: SH3 domain-containing kinase-binding protein 1

    Participant: SH3 domain-containing kinase-binding protein 1

    Accession: EBI-12601081

    Name: EBI-642709

    P
    Participant: SH3 domain-containing kinase-binding protein 1

    Participant: SH3 domain-containing kinase-binding protein 1

    Accession: EBI-12601081

    Name: EBI-642709

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: SH3 domain-containing kinase-binding protein 1

    Participant: SH3 domain-containing kinase-binding protein 1

    Accession: EBI-12601081

    Name: EBI-642709

    Stoichiometry: 0.0

    F
    Participant: SH3 domain-containing kinase-binding protein 1

    Participant: SH3 domain-containing kinase-binding protein 1

    Accession: EBI-12601081

    Name: EBI-642709

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: SH3 domain-containing kinase-binding protein 1

    Participant: SH3 domain-containing kinase-binding protein 1

    Accession: EBI-12601081

    Name: EBI-642709

    Confidences:

    Type
    Value
    No records found.

    6
    EBI-643570
     logo
    Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    Pik3r2
    Phosphatidylinositol 3-kinase regulatory subunit beta
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Accession: EBI-12601082

    Name: EBI-643570

    P
    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Accession: EBI-12601082

    Name: EBI-643570

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Accession: EBI-12601082

    Name: EBI-643570

    Stoichiometry: 0.0

    F
    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Accession: EBI-12601082

    Name: EBI-643570

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Participant: Phosphatidylinositol 3-kinase regulatory subunit beta

    Accession: EBI-12601082

    Name: EBI-643570

    Confidences:

    Type
    Value
    No records found.

    7
    EBI-300210
     logo
    Inpp5d
    Ship
    Inositol polyphosphate-5-phosphatase of 145 kDa

    [+4]
    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Accession: EBI-12601083

    Name: EBI-300210

    P
    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Accession: EBI-12601083

    Name: EBI-300210

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Accession: EBI-12601083

    Name: EBI-300210

    Stoichiometry: 0.0

    F
    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Accession: EBI-12601083

    Name: EBI-300210

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    Accession: EBI-12601083

    Name: EBI-300210

    Confidences:

    Type
    Value
    No records found.

    8
    EBI-647932
     logo
    Pik3cd
    Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Accession: EBI-12601084

    Name: EBI-647932

    P
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Accession: EBI-12601084

    Name: EBI-647932

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Accession: EBI-12601084

    Name: EBI-647932

    Stoichiometry: 0.0

    F
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Accession: EBI-12601084

    Name: EBI-647932

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Accession: EBI-12601084

    Name: EBI-647932

    Confidences:

    Type
    Value
    No records found.

    9
    EBI-359843
     logo
    Ywhag
    14-3-3 protein gamma
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: 14-3-3 protein gamma

    Participant: 14-3-3 protein gamma

    Accession: EBI-12601085

    Name: EBI-359843

    P
    Participant: 14-3-3 protein gamma

    Participant: 14-3-3 protein gamma

    Accession: EBI-12601085

    Name: EBI-359843

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: 14-3-3 protein gamma

    Participant: 14-3-3 protein gamma

    Accession: EBI-12601085

    Name: EBI-359843

    Stoichiometry: 0.0

    F
    Participant: 14-3-3 protein gamma

    Participant: 14-3-3 protein gamma

    Accession: EBI-12601085

    Name: EBI-359843

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: 14-3-3 protein gamma

    Participant: 14-3-3 protein gamma

    Accession: EBI-12601085

    Name: EBI-359843

    Confidences:

    Type
    Value
    No records found.

    10
    EBI-444641
     logo
    Ywhah
    14-3-3 protein eta
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: 14-3-3 protein eta

    Participant: 14-3-3 protein eta

    Accession: EBI-12601086

    Name: EBI-444641

    P
    Participant: 14-3-3 protein eta

    Participant: 14-3-3 protein eta

    Accession: EBI-12601086

    Name: EBI-444641

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: 14-3-3 protein eta

    Participant: 14-3-3 protein eta

    Accession: EBI-12601086

    Name: EBI-444641

    Stoichiometry: 0.0

    F
    Participant: 14-3-3 protein eta

    Participant: 14-3-3 protein eta

    Accession: EBI-12601086

    Name: EBI-444641

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: 14-3-3 protein eta

    Participant: 14-3-3 protein eta

    Accession: EBI-12601086

    Name: EBI-444641

    Confidences:

    Type
    Value
    No records found.

    11
    EBI-1688
     logo
    Grb2
    Adapter protein GRB2
    SH2/SH3 adapter GRB2
    Growth factor receptor-bound protein 2
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Growth factor receptor-bound protein 2

    Participant: Growth factor receptor-bound protein 2

    Accession: EBI-12601087

    Name: EBI-1688

    P
    Participant: Growth factor receptor-bound protein 2

    Participant: Growth factor receptor-bound protein 2

    Accession: EBI-12601087

    Name: EBI-1688

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Growth factor receptor-bound protein 2

    Participant: Growth factor receptor-bound protein 2

    Accession: EBI-12601087

    Name: EBI-1688

    Stoichiometry: 0.0

    F
    Participant: Growth factor receptor-bound protein 2

    Participant: Growth factor receptor-bound protein 2

    Accession: EBI-12601087

    Name: EBI-1688

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Growth factor receptor-bound protein 2

    Participant: Growth factor receptor-bound protein 2

    Accession: EBI-12601087

    Name: EBI-1688

    Confidences:

    Type
    Value
    No records found.

    12
    EBI-641748
     logo
    Phosphoinositide-3-kinase catalytic alpha polypeptide
    Serine/threonine protein kinase PIK3CA
    Pik3ca

    [+1]
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Accession: EBI-12601088

    Name: EBI-641748

    P
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Accession: EBI-12601088

    Name: EBI-641748

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Accession: EBI-12601088

    Name: EBI-641748

    Stoichiometry: 0.0

    F
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Accession: EBI-12601088

    Name: EBI-641748

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Participant: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    Accession: EBI-12601088

    Name: EBI-641748

    Confidences:

    Type
    Value
    No records found.

    13
    EBI-524514
     logo
    p59-Fyn
    Fyn
    Proto-oncogene c-Fyn
    Tyrosine-protein kinase Fyn
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Tyrosine-protein kinase Fyn

    Participant: Tyrosine-protein kinase Fyn

    Accession: EBI-12601089

    Name: EBI-524514

    P
    Participant: Tyrosine-protein kinase Fyn

    Participant: Tyrosine-protein kinase Fyn

    Accession: EBI-12601089

    Name: EBI-524514

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Tyrosine-protein kinase Fyn

    Participant: Tyrosine-protein kinase Fyn

    Accession: EBI-12601089

    Name: EBI-524514

    Stoichiometry: 0.0

    F
    Participant: Tyrosine-protein kinase Fyn

    Participant: Tyrosine-protein kinase Fyn

    Accession: EBI-12601089

    Name: EBI-524514

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Tyrosine-protein kinase Fyn

    Participant: Tyrosine-protein kinase Fyn

    Accession: EBI-12601089

    Name: EBI-524514

    Confidences:

    Type
    Value
    No records found.

    14
    EBI-443931
     logo
    Eps15-related protein
    Epidermal growth factor receptor pathway substrate 15-related sequence
    Eps15l1

    [+2]
    Epidermal growth factor receptor substrate 15-like 1
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Epidermal growth factor receptor substrate 15-like 1

    Participant: Epidermal growth factor receptor substrate 15-like 1

    Accession: EBI-12601090

    Name: EBI-443931

    P
    Participant: Epidermal growth factor receptor substrate 15-like 1

    Participant: Epidermal growth factor receptor substrate 15-like 1

    Accession: EBI-12601090

    Name: EBI-443931

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Epidermal growth factor receptor substrate 15-like 1

    Participant: Epidermal growth factor receptor substrate 15-like 1

    Accession: EBI-12601090

    Name: EBI-443931

    Stoichiometry: 0.0

    F
    Participant: Epidermal growth factor receptor substrate 15-like 1

    Participant: Epidermal growth factor receptor substrate 15-like 1

    Accession: EBI-12601090

    Name: EBI-443931

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Epidermal growth factor receptor substrate 15-like 1

    Participant: Epidermal growth factor receptor substrate 15-like 1

    Accession: EBI-12601090

    Name: EBI-443931

    Confidences:

    Type
    Value
    No records found.

    15
    EBI-12600383
     logo
    Grap
    GRB2-related adapter protein
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: GRB2-related adapter protein

    Participant: GRB2-related adapter protein

    Accession: EBI-12601091

    Name: EBI-12600383

    P
    Participant: GRB2-related adapter protein

    Participant: GRB2-related adapter protein

    Accession: EBI-12601091

    Name: EBI-12600383

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: GRB2-related adapter protein

    Participant: GRB2-related adapter protein

    Accession: EBI-12601091

    Name: EBI-12600383

    Stoichiometry: 0.0

    F
    Participant: GRB2-related adapter protein

    Participant: GRB2-related adapter protein

    Accession: EBI-12601091

    Name: EBI-12600383

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: GRB2-related adapter protein

    Participant: GRB2-related adapter protein

    Accession: EBI-12601091

    Name: EBI-12600383

    Confidences:

    Type
    Value
    No records found.

    16
    EBI-773469
     logo
    3-methylcrotonyl-CoA carboxylase 1
    3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha
    3-methylcrotonyl-CoA carboxylase biotin-containing subunit

    [+2]
    Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Accession: EBI-12601092

    Name: EBI-773469

    P
    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Accession: EBI-12601092

    Name: EBI-773469

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Accession: EBI-12601092

    Name: EBI-773469

    Stoichiometry: 0.0

    F
    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Accession: EBI-12601092

    Name: EBI-773469

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Participant: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

    Accession: EBI-12601092

    Name: EBI-773469

    Confidences:

    Type
    Value
    No records found.

    17
    EBI-350896
     logo
    Tubb5
    Tubulin beta-5 chain
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Tubulin beta-5 chain

    Participant: Tubulin beta-5 chain

    Accession: EBI-12601093

    Name: EBI-350896

    P
    Participant: Tubulin beta-5 chain

    Participant: Tubulin beta-5 chain

    Accession: EBI-12601093

    Name: EBI-350896

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Tubulin beta-5 chain

    Participant: Tubulin beta-5 chain

    Accession: EBI-12601093

    Name: EBI-350896

    Stoichiometry: 0.0

    F
    Participant: Tubulin beta-5 chain

    Participant: Tubulin beta-5 chain

    Accession: EBI-12601093

    Name: EBI-350896

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Tubulin beta-5 chain

    Participant: Tubulin beta-5 chain

    Accession: EBI-12601093

    Name: EBI-350896

    Confidences:

    Type
    Value
    No records found.

    18
    EBI-12600513
     logo
    Cd5
    Ly-1
    Lymphocyte antigen 1
    T-cell surface glycoprotein CD5
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: T-cell surface glycoprotein CD5

    Participant: T-cell surface glycoprotein CD5

    Accession: EBI-12601094

    Name: EBI-12600513

    P
    Participant: T-cell surface glycoprotein CD5

    Participant: T-cell surface glycoprotein CD5

    Accession: EBI-12601094

    Name: EBI-12600513

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: T-cell surface glycoprotein CD5

    Participant: T-cell surface glycoprotein CD5

    Accession: EBI-12601094

    Name: EBI-12600513

    Stoichiometry: 0.0

    F
    Participant: T-cell surface glycoprotein CD5

    Participant: T-cell surface glycoprotein CD5

    Accession: EBI-12601094

    Name: EBI-12600513

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: T-cell surface glycoprotein CD5

    Participant: T-cell surface glycoprotein CD5

    Accession: EBI-12601094

    Name: EBI-12600513

    Confidences:

    Type
    Value
    No records found.

    19
    EBI-356480
     logo
    Ywhae
    14-3-3 protein epsilon
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-12601095

    Name: EBI-356480

    P
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-12601095

    Name: EBI-356480

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-12601095

    Name: EBI-356480

    Stoichiometry: 0.0

    F
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-12601095

    Name: EBI-356480

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-12601095

    Name: EBI-356480

    Confidences:

    Type
    Value
    No records found.

    20
    EBI-2906540
     logo
    Crk
    Crko
    Proto-oncogene c-Crk

    [+1]
    Adapter molecule crk
    Mus musculus
    Organism Details

    Accession: EBI-1329

    Name: mouse

    Description: Mus musculus

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    -
    mouse

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Adapter molecule crk

    Participant: Adapter molecule crk

    Accession: EBI-12601096

    Name: EBI-2906540

    P
    Participant: Adapter molecule crk

    Participant: Adapter molecule crk

    Accession: EBI-12601096

    Name: EBI-2906540

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Adapter molecule crk

    Participant: Adapter molecule crk

    Accession: EBI-12601096

    Name: EBI-2906540

    Stoichiometry: 0.0

    F
    Participant: Adapter molecule crk

    Participant: Adapter molecule crk

    Accession: EBI-12601096

    Name: EBI-2906540

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Adapter molecule crk

    Participant: Adapter molecule crk

    Accession: EBI-12601096

    Name: EBI-2906540

    Confidences:

    Type
    Value
    No records found.


    Graphical Representation of Experimental Features